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DTX2 and PSMB4
Data Source:
BioGRID
(two hybrid)
DTX2
PSMB4
Description
deltex E3 ubiquitin ligase 2
proteasome 20S subunit beta 4
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Nuclear Membrane
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Beta-subunit Complex
Ciliary Basal Body
Extracellular Exosome
Molecular Function
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Activity
Lipopolysaccharide Binding
Endopeptidase Activity
Threonine-type Endopeptidase Activity
Protein Binding
Biological Process
Notch Signaling Pathway
Protein Ubiquitination
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS
Blood trace element (Cu levels) (
23720494
)
Body mass index (
26426971
)
Interacting Genes
131 interacting genes:
ABHD11
ABHD16A
ALKBH4
ANAPC11
ANTKMT
ARID5A
ARMC7
ARNT2
BCL2L11
BICRAL
BOLA2-SMG1P6
C10orf55
C11orf1
C19orf54
C1orf94
C20orf85
C22orf39
CCDC57
CLPP
COA6
COQ8A
DAZAP2
DOK3
DTX1
DTX3
ECM1
ECSIT
EIF4ENIF1
EIF4G1
EYA2
FAM168A
FCRL4
FHL2
FHL5
FOXI1
FTO
GLYCTK
GOLGA2
HDC
HGS
HLX
HOXA1
HOXB2
HOXD12
HPCA
HPCAL1
HPCAL4
HSFY1
HSFY2
IKZF3
KANK2
KLC3
KLHDC7B
KRTAP11-1
KRTAP13-3
KRTAP15-1
KRTAP19-1
KRTAP19-6
KRTAP19-7
KRTAP26-1
KRTAP6-1
KRTAP7-1
KRTAP8-1
LASP1
LNX1
LRP2BP
MBD3L1
MDC1
MED19
MSS51
MVP
MXRA8
NCALD
NCS1
NHLRC4
NIF3L1
NME4
NOTCH1
OIP5
PARP1
PAX5
PLEKHF2
PLEKHG4
PLSCR1
POGZ
PPP1R32
PRR32
PRR34
PSMB4
QARS1
RBM11
RBPMS
RFX6
RHOXF2
RIMBP3
RUNX1
RUSC1
SEC22A
SEC23A
SEC23B
SEPSECS
SLC22A18AS
SOHLH1
SPAG8
SPG21
STX12
SUMO1
TBX15
TEKT5
TENT2
TMEM42
TRIB3
TRIM35
TRIM54
TRIP13
TRIP6
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBQLN4
USP54
VGLL3
VSNL1
ZNF34
ZNF503
ZNF620
ZNF641
ZNF764
ZNF774
ZNF85
35 interacting genes:
APP
BCL6
C1orf109
CCDC57
CNOT2
CUL1
DTX2
FSD2
GABARAPL1
GCA
HEMK1
HGS
KANK2
KRTAP19-5
MYOZ3
OAZ1
P4HA3
PFDN5
PITX2
PKN1
PLK1
PRKCA
PROP1
PRPF19
PSMB1
PSMB5
PSMD2
PSMG3
SMAD1
SOHLH1
SPG21
SYNPO2L
TEKT5
TFAP2D
TLE5
Entrez ID
113878
5692
HPRD ID
16841
03710
Ensembl ID
ENSG00000091073
ENSG00000159377
Uniprot IDs
Q86UW9
A0A140VK46
P28070
PDB IDs
6IR0
6Y22
6Y2X
6Y3J
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
Enriched GO Terms of Interacting Partners
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