TUSC2 and FHL5

Data Source:
BioGRID (two hybrid)

		TUSC2	FHL5
Description		tumor suppressor 2, mitochondrial calcium regulator	four and a half LIM domains 5
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleus Z Disc
	Molecular Function	Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Metal Ion Binding
	Biological Process	Natural Killer Cell Differentiation Phagocytosis Inflammatory Response Cell Cycle Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-10 Production Cell Maturation Regulation Of Mitochondrial Membrane Potential Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Reactive Oxygen Species Metabolic Process	Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Cerebral blood flow ( 28627999) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Headache ( 29397368) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418) Spatial memory ( 31596458)
Interacting Genes		4 interacting genes: FHL5 MAPK9 MDFI RBPMS	90 interacting genes: ABI2 ADAM12 ADAMTSL5 AGXT ANKRD55 ANKS1A BANP BBC3 BCL6B CATSPER1 CDC20B CFP CNNM3 COIL CREB1 CREM CRYBA2 CRYBA4 CTSZ DCDC2B DLGAP4 DMRT3 DNAL4 DTX2 FAM214B FAM71C FARS2 FEZF1 FHL2 GPS2 GSTP1 HAPLN2 HCK HDX HEY2 HOXA1 HOXB9 IL16 IP6K3 KIF17 KIR2DL4 LMO2 LRRC41 MAGOHB MISP MYOZ3 NEK6 NPDC1 NUFIP2 OTX1 PIN1 PLEKHA2 PLEKHN1 PPP1R18 PPP1R32 QRICH1 RAB26 RAB3IL1 RPS21 SAXO1 SCNM1 SDCBP SEC31A SHFL SLIT1 SMAD1 SPRY1 SRF TUSC2 TXN2 YPEL3 ZBTB16 ZNF124 ZNF131 ZNF23 ZNF250 ZNF251 ZNF408 ZNF417 ZNF440 ZNF446 ZNF564 ZNF581 ZNF587 ZNF613 ZNF688 ZNF764 ZNF766 ZNF792 ZNHIT1
Entrez ID		11334	9457
HPRD ID		06134	05497
Ensembl ID		ENSG00000114383	ENSG00000112214
Uniprot IDs		O75896	Q5TD97
PDB IDs			1X68
Enriched GO Terms of Interacting Partners?
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