CHRM4 and EEF1A2

Data Source:
HPRD (in vitro, in vivo)

		CHRM4	EEF1A2
Description		cholinergic receptor muscarinic 4	eukaryotic translation elongation factor 1 alpha 2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse Postsynaptic Membrane	Nucleus Cytoplasm Eukaryotic Translation Elongation Factor 1 Complex Neuronal Cell Body Synapse Cytoplasmic Side Of Lysosomal Membrane
	Molecular Function	G Protein-coupled Serotonin Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Protein Kinase Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Locomotion G Protein-coupled Serotonin Receptor Signaling Pathway	Translation Translational Elongation Response To Inorganic Substance Positive Regulation Of Apoptotic Process Response To Electrical Stimulus Positive Regulation Of Lipid Kinase Activity Regulation Of Chaperone-mediated Autophagy
Pathways		Muscarinic acetylcholine receptors G alpha (i) signalling events	Eukaryotic Translation Elongation
Drugs		Ziprasidone Amitriptyline Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Procyclidine Loxapine Carbamoylcholine Hyoscyamine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Tropicamide Brompheniramine Maprotiline Methantheline Bethanechol Tolterodine Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine ALKS 27 Fesoterodine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 23535732)
Interacting Genes		20 interacting genes: B2M CBFA2T3 CD59 CD81 EEF1A2 ERGIC3 GPRASP1 GRB2 MCL1 METTL9 MFSD4A QSOX1 RAB3A RHBDD2 RTN4 SMIM7 SYN2 TM7SF2 TSPAN7 YIPF3	10 interacting genes: ABTB1 CHRM4 ERG MAPK6 SMN1 STK11 SUMO2 TPT1 TSPY1 TTLL12
Entrez ID		1132	1917
HPRD ID		00330	04265
Ensembl ID		ENSG00000180720	ENSG00000101210
Uniprot IDs		P08173	Q05639
PDB IDs		5DSG 6D9H 6KP6	3C5J
Enriched GO Terms of Interacting Partners?
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