POU6F2 and THADA

Data Source:
BioGRID (two hybrid)

		POU6F2	THADA
Description		POU class 6 homeobox 2	THADA armadillo repeat containing
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytosol Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Ganglion Mother Cell Fate Determination Central Nervous System Development Visual Perception	TRNA Methylation Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Lipid Homeostasis Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Adaptive Thermogenesis
Pathways			tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Adult body size ( 32376654) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Feeling hurt ( 29500382) Glaucoma (multi-trait analysis) ( 31959993) Hand grip strength ( 29691431) Intraocular pressure ( 29785010 31959993 30054594) Motion sickness ( 25628336) Refractive error ( 32231278) Tea consumption ( 31046077)	Alopecia areata ( 25337690) Apolipoprotein B levels ( 32203549) Blood glucose levels ( 31928498) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Diastolic blood pressure ( 31469255) DNA methylation (variation) ( 23725790) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Glomerular filtration rate (creatinine) ( 26831199) Glucose homeostasis traits ( 25524916) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Hair morphology ( 19896111) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998 29785010 31959993 30054594) Latent autoimmune diabetes ( 30254083) LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 27182965 28196072) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Mitochondrial DNA levels ( 25240745) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 22190364) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Orofacial clefts ( 20023658 22863734) Platelet count ( 22139419 32888494) Plateletcrit ( 32888494 27863252) Polycystic ovary syndrome ( 30566500 26416764 21151128) Prostate cancer ( 31562322 19767753) Red blood cell count ( 32888494) Response to amphetamines ( 22952603) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 22885922 18372903 30054458 29358691 30297969 29632382 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Viral capsid antigen IgG seropositivity ( 29868224)
Interacting Genes		143 interacting genes: ACTN3 ANKRD10 ARHGEF6 ASB13 BANP BFSP2 BHLHE40 C1orf109 C5 CCHCR1 CCNC CCNK CDC23 CDC37 CDKN2C CHAF1A CIB3 CINP CSNK2A1 CSTF2 CTNNA3 DDX6 DTNB DYDC1 EBF1 EIF3F EIF4EBP1 EPHB6 FHL2 FNDC3B FOSB GCM2 GLIS2 GMEB2 GOLGA6L9 HGS HIVEP1 HNF1B HOXC5 HOXC8 HSPA4 IGFN1 IMPDH2 IQUB IRX4 ISX KDF1 KIF5B KLHL11 KPNA5 KPNA6 KRTAP8-1 L3MBTL2 LARP4 LMNB2 LMO3 LNX1 LONRF1 MAGEA12 MAPK9 MEIS2 MIEN1 MLLT10 MORF4L2 MSRB3 MSX2 MYL7 MYO15B NEUROG3 NFYC NKX3-2 NME7 NUP62CL OAZ3 OIP5 OPLAH OPTN PADI4 PARVG PDE6H PIBF1 PKN1 PM20D2 POLR3C POU2F1 PPIL1 PPIP5K2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAD23B RBM39 RBPMS RELA SIX1 SMAD5 SMYD1 SORL1 SOX10 SSUH2 STAC STRA8 TBX6 TCEA2 TENT5B THADA THAP1 TLX2 TLX3 TNPO2 TNXB TP53BP1 TRIM73 TRIML2 TSC1 TSEN15 TTC19 TTC23 UBAC1 UFSP1 VAX2 VENTX VEZF1 VPS9D1 XPOT ZBTB24 ZBTB4 ZFHX2 ZFHX3 ZFP1 ZFP91 ZIM2 ZMYND12 ZNF148 ZNF319 ZNF34 ZNF384 ZNF410 ZNF574	2 interacting genes: POU6F2 USHBP1
Entrez ID		11281	63892
HPRD ID		10162	18177
Ensembl ID		ENSG00000106536	ENSG00000115970
Uniprot IDs		P78424	Q6YHU6
PDB IDs			5T6Y
Enriched GO Terms of Interacting Partners?
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