KLHL2 and KLHL12

Data Source:
BioGRID (two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		KLHL2	KLHL12
Description		kelch like family member 2	kelch like family member 12
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Protein Ubiquitination Post-translational Protein Modification	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Degradation of DVL
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		31 interacting genes: ACTC1 BCAM BYSL C20orf85 CCDC43 CDC37 CLK2 CUL3 CWC22 ELOA KEAP1 KLHL12 KLHL3 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	62 interacting genes: ARAF ARRDC1 ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL1 DVL2 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDGFRB PEA15 PEF1 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		11275	59349
HPRD ID		09311	13925
Ensembl ID		ENSG00000109466	ENSG00000117153
Uniprot IDs		B4DFZ5 E9PEX9 O95198	Q53G59 Q9H7R2
PDB IDs		2XN4 4CHB	2VPJ 6TTK 6V7O
Enriched GO Terms of Interacting Partners?
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