ATXN2L and MPL

Data Source:
HPRD (in vivo)

		ATXN2L	MPL
Description		ataxin 2 like	MPL proto-oncogene, thrombopoietin receptor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoplasmic Stress Granule Membrane Nuclear Speck	Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Membrane Neuron Projection Neuronal Cell Body
	Molecular Function	RNA Binding Protein Binding Cadherin Binding	Protein Binding Thrombopoietin Receptor Activity
	Biological Process	Regulation Of Cytoplasmic MRNA Processing Body Assembly Stress Granule Assembly	Neutrophil Homeostasis Monocyte Homeostasis Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Platelet Aggregation Cellular Response To Hypoxia Positive Regulation Of Platelet Formation Eosinophil Homeostasis Basophil Homeostasis
Pathways			Platelet Aggregation (Plug Formation)
Drugs			Romiplostim SB-559448 Eltrombopag Thrombopoietin Avatrombopag Lusutrombopag
Diseases			Congenital amegakaryocytic thrombocytopenia (CAMT)
GWAS		Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29679657) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 28552196 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Crohn's disease ( 28067908) Educational attainment ( 25201988 23722424) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Extremely high intelligence ( 29520040) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Left-handedness ( 32989287) Pediatric autoimmune diseases ( 26301688) Waist circumference ( 28552196) Weight ( 28552196)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		39 interacting genes: ATXN1 BOLL EPOR HADHA KRTAP12-4 MIR1-1 MIR10B MIR128-1 MIR128-2 MIR15B MIR16-2 MIR17 MIR19A MIR200C MIR205 MIR20B MIR21 MIR214 MIR25 MIR31 MIR34A MIR34B MIR363 MIR7-1 MIR7-2 MIR7-3 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MPL	9 interacting genes: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ
Entrez ID		11273	4352
HPRD ID		06394	01161
Ensembl ID		ENSG00000168488	ENSG00000117400
Uniprot IDs		H3BUF6 Q8WWM7	P40238
PDB IDs
Enriched GO Terms of Interacting Partners?
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