CHP1 and PRSS23

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CHP1	PRSS23
Description		calcineurin like EF-hand protein 1	serine protease 23
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion Microtubule Cytoskeleton Transport Vesicle Extracellular Exosome	Nucleus Endoplasmic Reticulum Lumen Extracellular Exosome
	Molecular Function	Protein Kinase Inhibitor Activity Calcium Ion Binding Protein Binding Microtubule Binding Potassium Channel Regulator Activity Kinase Binding Calcium-dependent Protein Binding	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Microtubule Bundle Formation Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Protein Export From Nucleus Potassium Ion Transport Vesicle Targeting Vesicle Fusion Small GTPase Mediated Signal Transduction Negative Regulation Of Phosphatase Activity Membrane Docking Hyaluronan Catabolic Process Cytoplasmic Microtubule Organization Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Protein Import Into Nucleus Protein Stabilization Positive Regulation Of Protein Transport Protein Complex Oligomerization Regulation Of Intracellular PH Positive Regulation Of Protein Glycosylation Membrane Organization Membrane Fusion Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Phospholipid Biosynthetic Process Cellular Response To Acidic PH Positive Regulation Of Protein Targeting To Membrane Regulation Of Neuron Death	Proteolysis Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Hyaluronan uptake and degradation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Essential hypertension (time to event) ( 32589924) Estimated glomerular filtration rate ( 31015462) Ulcerative colitis ( 28067908) White blood cell count ( 32888494)	Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998 29785010) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		10 interacting genes: GAPDH KIF1B PRSS23 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 STK17B UBC	26 interacting genes: ACTG1 APP B2M CHP1 EFNA3 FXR1 GATD1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SEC11C SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4
Entrez ID		11261	11098
HPRD ID		06101	07149
Ensembl ID		ENSG00000187446	ENSG00000150687
Uniprot IDs		A0A024R9M9 H0YKE7 Q99653	O95084
PDB IDs		2E30
Enriched GO Terms of Interacting Partners?
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