PACSIN2 and COBL

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		PACSIN2	COBL
Description		protein kinase C and casein kinase substrate in neurons 2	cordon-bleu WH2 repeat protein
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Caveola Cell-cell Junction Focal Adhesion Nuclear Speck Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Ruffle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse	Ruffle Actin Filament Plasma Membrane Cell Cortex Membrane Axon Dendrite Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Terminal Web
	Molecular Function	Transporter Activity Protein Binding Phospholipid Binding Identical Protein Binding Cadherin Binding Phosphatidic Acid Binding	Actin Monomer Binding Protein Binding
	Biological Process	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Endocytosis Protein Localization To Endosome Negative Regulation Of Endocytosis Cell Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Membrane Organization Caveola Assembly Caveolin-mediated Endocytosis Plasma Membrane Tubulation	Embryonic Axis Specification Somite Specification Neural Tube Closure Liver Development Actin Filament Polymerization Notochord Development Floor Plate Development Digestive Tract Development Collateral Sprouting In Absence Of Injury Actin Filament Network Formation Positive Regulation Of Dendrite Development Positive Regulation Of Ruffle Assembly
Pathways		Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Prostate cancer (SNP x SNP interaction) ( 22219177)	Autoimmune traits (pleiotropy) ( 30572963) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Fractures ( 30158200) Late-onset Alzheimer's disease ( 27770636) Macular thickness ( 30535121) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730) Type 1 diabetes ( 19430480) Urate levels in obese individuals ( 25811787) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 26480920) Wegener's granulomatosis ( 23740775)
Interacting Genes		16 interacting genes: COBL DNM1 FASLG GSC2 MEOX2 PACSIN1 PACSIN3 PBX4 POT1 RIC8A SHBG SYNJ1 TERF1 TERF2IP TRPV4 WASL	2 interacting genes: ALAS1 PACSIN2
Entrez ID		11252	23242
HPRD ID		05390	10843
Ensembl ID		ENSG00000100266	ENSG00000106078
Uniprot IDs		Q6FIA3 Q9UNF0	O75128
PDB IDs		3ABH 3ACO 3HAJ 3Q0K	4PL8
Enriched GO Terms of Interacting Partners?
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