HNRNPA0 and MTNR1B

Data Source:
HPRD (in vivo)

		HNRNPA0	MTNR1B
Description		heterogeneous nuclear ribonucleoprotein A0	melatonin receptor 1B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Plasma Membrane Integral Component Of Plasma Membrane Synapse
	Molecular Function	RNA Binding MRNA Binding Protein Kinase Binding MRNA 3'-UTR AU-rich Region Binding	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Inflammatory Response RNA Metabolic Process Response To Lipopolysaccharide 3'-UTR-mediated MRNA Stabilization	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Negative Regulation Of CGMP-mediated Signaling Glucose Homeostasis Camera-type Eye Development Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Neuronal Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs			Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases			Type II diabetes mellitus
GWAS			Acute insulin response ( 28490609) Adverse response to radiation therapy ( 23719583) Birth weight ( 31043758 27680694) Chronotype ( 30696823) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Depressive symptoms x dependent stressful life events interaction (1df test) ( 30718454) Depressive symptoms x dependent stressful life events interaction (2df test) ( 30718454) Diabetes (gestational) ( 22233651) Fasting blood glucose ( 29844224 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374 19060907 19060909 19651812 22508271) Glucose homeostasis traits ( 25524916) Glycated hemoglobin levels ( 20858683 28898252) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Glycemic traits (pregnancy) ( 23903356) Hemoglobin A1c levels ( 29403010) High fasting blood glucose ( 31910446) Homeostasis model assessment of beta-cell function ( 20081858) Incremental insulin ( 24699409) Insomnia (caffeine-induced) ( 22754043) Insulin disposition index ( 24699409 28490609) Insulin levels ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin secretion rate ( 28490609) Insulin-related traits (multivariate analysis) ( 32002517) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 21909109 22286219) Metabolite levels (small molecules and protein measures) ( 27005778) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758 29309628) Peak insulin response ( 28490609) Pulse pressure ( 30224653 30578418) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 28254843 32499647 20581827 28869590) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658)
Interacting Genes		88 interacting genes: CCT3 CIRBP CLK1 DDX5 HNRNPF HNRNPH2 HNRNPH3 HNRNPK IL7R MAPK6 MAPKAPK2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MTNR1A MTNR1B NKX3-1 SRSF1 SUMO2	133 interacting genes: ACKR1 ACTN1 ADCY3 ANXA6 AP1B1 AP4E1 APOL6 ARHGAP1 ARHGAP28 ATP6V0B BCL2L1 BCL2L13 BTBD1 CANX CD99 CDC16 CDH11 CDH13 CDH4 CLASP1 CLDND1 COG4 COG8 COPA COX11 CRELD1 CSE1L CTNNA1 CTNND1 CUL3 DISP3 DMXL2 DST DYNC1H1 DYNC2H1 EBF1 EBP EIF3A ERG28 ESPL1 EVA1A FANCI FLNA FSTL1 FTL GGT7 GNAI1 GNAI2 GNAI3 GNAS GNB1 GNB2 GNB4 GPM6B GPR50 HARS1 HECTD1 HNRNPA0 HSPA5 INTS1 IPO4 IPO9 IRF2BP2 IRS4 ITM2C ITPR3 KMT2C LTBR MACF1 MARCHF6 MARF1 MFF MIA3 MMP2 MON2 MTMR6 MTNR1A OTX1 PCDHB10 PCNX4 PDIA3 PDIA6 PEAK1 PI4KA PIDD1 POLI PPM1G PPP1R21 PPP6R1 PRKDC PSMD8 PSME3IP1 PTPRD RECK RIPOR2 RNF185 RNF40 RNF41 RPRD2 SDHD SF3A3 SLC12A4 SLC2A3 SLC30A1 SLC39A6 SLC3A2 SLC4A7 SMARCD1 SMC3 SREBF1 SREBF2 STMN4 SYNE2 TANGO6 TBCD THOC1 THRA TINF2 TLN1 TMEM14A TMEM230 TRIM24 TRIM46 TRIP12 UBAP2L UBQLN2 UBQLN4 UBR4 USP34 VPS35 XBP1 YWHAB YWHAQ
Entrez ID		10949	4544
HPRD ID		17112	02882
Ensembl ID		ENSG00000177733	ENSG00000134640
Uniprot IDs		Q13151	P49286
PDB IDs			6ME6 6ME7 6ME8 6ME9
Enriched GO Terms of Interacting Partners?
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