KDM5B and PAX9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		KDM5B	PAX9
Description		lysine demethylase 5B	paired box 9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Chromatin Nucleus
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-trimethyl-K4 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific) Histone Binding Dioxygenase Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Single Fertilization Post-embryonic Development Positive Regulation Of Gene Expression Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Response To Fungicide Uterus Morphogenesis Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Regulation Of Estradiol Secretion	Regulation Of Transcription By RNA Polymerase II Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development Face Morphogenesis Cellular Response To Growth Factor Stimulus
Pathways		HDMs demethylate histones TFAP2 (AP-2) family regulates transcription of cell cycle factors
Drugs
Diseases			Tooth agenesis; Hypodontia
GWAS			Breast cancer ( 29059683 23535729) Height ( 28552196) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Nonsyndromic cleft palate ( 31609978) Prostate cancer ( 29892016)
Interacting Genes		5 interacting genes: FOXG1 KDM1A MBD3 PAX9 RB1	26 interacting genes: EYA2 FUBP3 GTF2A1L KDM5B KLF4 KRTAP13-3 LMO2 MSX1 MYLIP NR0B2 PFDN5 PLAGL2 SFN SLAIN1 SSX4 TEPSIN TLE1 TLE2 TLE5 TRIP13 TRIP4 VPS37C WWOX ZNF343 ZNF440 ZNF580
Entrez ID		10765	5083
HPRD ID		09251	01336
Ensembl ID		ENSG00000117139	ENSG00000198807
Uniprot IDs		A0A3B3ITA8 Q9UGL1	P55771 Q2L4T1
PDB IDs		2MA5 2MNY 2MNZ 5A1F 5A3N 5A3P 5A3T 5A3W 5FPL 5FPU 5FUN 5FUP 5FV3 5FY4 5FY5 5FY9 5FYB 5FYS 5FYT 5FYU 5FYV 5FYY 5FYZ 5FZ0 5FZ1 5FZ3 5FZ4 5FZ6 5FZ7 5FZ8 5FZ9 5FZA 5FZB 5FZC 5FZD 5FZE 5FZF 5FZG 5FZH 5FZI 5FZK 5FZL 5FZM 5LW9 5LWB 6EIN 6EIU 6EIY 6EJ0 6EJ1 6EK6 6H4Z 6H50 6H51 6H52 6RBI
Enriched GO Terms of Interacting Partners?
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