OGA and OGT

Data Source:
BioGRID (affinity chromatography technology, pull down, pull down, enzymatic study)

		OGA	OGT
Description		O-GlcNAcase	O-linked N-acetylglucosamine (GlcNAc) transferase
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GO Annotations	Cellular Component	Nucleus Cytosol Membrane	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytosol Plasma Membrane Protein N-acetylglucosaminyltransferase Complex Mitochondrial Membrane Protein-containing Complex Cell Projection
	Molecular Function	Hyalurononglucosaminidase Activity Beta-N-acetylglucosaminidase Activity [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase Activity [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase Activity [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase Activity	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Acetylglucosaminyltransferase Activity Protein N-acetylglucosaminyltransferase Activity Protein O-GlcNAc Transferase Activity
	Biological Process	N-acetylglucosamine Metabolic Process Protein O-linked Glycosylation Glycoprotein Catabolic Process Protein Deglycosylation Glycoprotein Metabolic Process Viral Process	Regulation Of Glycolytic Process Regulation Of Gluconeogenesis Regulation Of Transcription By RNA Polymerase II Protein O-linked Glycosylation Apoptotic Process Signal Transduction Response To Nutrient Viral Process Protein Processing Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Rac Protein Signal Transduction Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Histone H3-K27 Methylation Histone H3-K4 Trimethylation Positive Regulation Of Cold-induced Thermogenesis
Pathways			HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases
Drugs		Streptozocin
Diseases
GWAS			Red cell distribution width ( 32888494)
Interacting Genes		10 interacting genes: A2M C6 CDC37 CSNK2B DHX9 GSK3B MAST1 OGT PSEN2 RNF32	28 interacting genes: CSNK2A1 CSNK2B GSK3B HCFC1 HIRA HIVEP1 MAPT MTDH NUP62 NUP62CL OGA PHC3 PSG1 SAP30BP SCAI SIN3A SNAP91 SP1 SRF TAB1 TAB3 TET2 TRAF7 TRAK1 TRAK2 UBC YES1 ZNF124
Entrez ID		10724	8473
HPRD ID		04949	02222
Ensembl ID		ENSG00000198408	ENSG00000147162
Uniprot IDs		O60502	O15294
PDB IDs		2YDQ 5M7R 5M7S 5M7T 5M7U 5TKE 5UHK 5UHL 5UHO 5UHP 5UN8 5UN9 5VVO 5VVT 5VVU 5VVV 5VVX 6HKI 6PM9	1W3B 3PE3 3PE4 3TAX 4AY5 4AY6 4CDR 4GYW 4GYY 4GZ3 4GZ5 4GZ6 4N39 4N3A 4N3B 4N3C 4XI9 4XIF 5BNW 5C1D 5HGV 5LVV 5LWV 5NPR 5NPS 5VIE 5VIF 6E37 6EOU 6IBO 6MA1 6MA2 6MA3 6MA4 6MA5 6Q4M 6TKA
Enriched GO Terms of Interacting Partners?
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