CAMKK2 and CAMK1

Data Source:
HPRD (in vitro)

		CAMKK2	CAMK1
Description		calcium/calmodulin dependent protein kinase kinase 2	calcium/calmodulin dependent protein kinase I
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Neuron Projection	Intracellular Anatomical Structure Nucleus Cytosol Postsynaptic Density Glutamatergic Synapse
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding	Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling Cellular Response To Reactive Oxygen Species Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation CAMKK-AMPK Signaling Cascade Positive Regulation Of Autophagy Of Mitochondrion	Protein Phosphorylation Nucleocytoplasmic Transport Cell Cycle Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Cell Differentiation Negative Regulation Of Protein Binding Regulation Of Protein Localization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Regulation Of Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Dendritic Spine Development Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Acetylation Regulation Of Histone H3-K9 Acetylation
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs	Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		Left ventricular obstructive tract defect (inherited effect) ( 28468790) Type 2 diabetes ( 29358691)
Interacting Genes		7 interacting genes: APP CALM1 CAMK1 CAMK4 CEP63 NEDD4 PRKACA	22 interacting genes: APP ATF1 ATXN1 CALM1 CAMKK1 CAMKK2 CCND1 CDK4 CDKN1B EIF4G3 FBXO7 GAPDH GCM1 HDAC5 HSPB1 IL16 MARK2 NOS1 PIK3R3 PPME1 PPP2CA SYN1
Entrez ID		10645	8536
HPRD ID		06467	05412
Ensembl ID		ENSG00000110931	ENSG00000134072
Uniprot IDs		A0A024RBP6 A0A024RBP8 A0A024RBQ0 A0A024RBQ3 Q96RR4	B0YIY3 Q14012
PDB IDs		2ZV2 5UY6 5UYJ 5VT1 5YV8 5YV9 5YVA 5YVB 5YVC 6BKU 6BLE 6BQL 6BQP 6BQQ 6BRC 6CMJ 6EF5 6EWW 6FEL 6Y8A	4FG7 4FG8 4FG9 4FGB
Enriched GO Terms of Interacting Partners?
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