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RBCK1 and NR1I2
Data Source:
BioGRID
(pull down)
RBCK1
NR1I2
Description
RANBP2-type and C3HC4-type zinc finger containing 1
nuclear receptor subfamily 1 group I member 2
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Cytosol
LUBAC Complex
Chromatin
Nucleoplasm
Nuclear Body
Intermediate Filament Cytoskeleton
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Identical Protein Binding
Ubiquitin Binding
Metal Ion Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Nuclear Receptor Activity
Protein Binding
Drug Binding
Zinc Ion Binding
Nuclear Receptor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Protein Polyubiquitination
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Necroptotic Process
Protein Linear Polyubiquitination
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Xenobiotic Metabolic Process
Signal Transduction
Steroid Metabolic Process
Cell Differentiation
Intracellular Receptor Signaling Pathway
Exogenous Drug Catabolic Process
Xenobiotic Transport
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Vitamin E
Oxiconazole
Phenytoin
Diethylstilbestrol
Clotrimazole
Pentobarbital
Spironolactone
Lindane
Flutamide
Ritonavir
Erlotinib
Cyclophosphamide
Mephenytoin
Carbamazepine
Tamoxifen
Warfarin
Ethotoin
Estradiol
Mifepristone
Methylphenobarbital
Ethinylestradiol
Ketoconazole
Fenofibrate
Rifampicin
Clonazepam
Miconazole
Nifedipine
Econazole
Sulfinpyrazone
Phenobarbital
Ifosfamide
Rifaximin
Paclitaxel
Dexamethasone
Docetaxel
Bezafibrate
Genistein
Prasterone
Hyperforin
Resveratrol
Pregnenolone
Quercetin
SR12813
Afimoxifene
Phenolphthalein
Permethrin
Dovitinib
Chenodeoxycholic acid
TO-901317
Hexestrol
Triclosan
Rilpivirine
Pyrethrum extract
Myrrh
Piperine
Troleandomycin
Fenofibric acid
Estradiol acetate
Estradiol benzoate
Estradiol cypionate
Estradiol dienanthate
Estradiol valerate
alpha-Tocopherol succinate
D-alpha-Tocopherol acetate
Dexamethasone acetate
Diseases
GWAS
Night sleep phenotypes (
27126917
)
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Hippocampal volume in Alzheimer's disease dementia (
29274321
)
LDL cholesterol levels (
32203549
)
Lymphocyte percentage of white cells (
32888494
)
Total cholesterol levels (
30275531
)
Interacting Genes
65 interacting genes:
APP
ARNT2
BACH1
CREB5
CREBBP
ENKD1
GLYCTK
HGS
HOXA1
HOXC8
IL16
IREB2
KANK2
LNX1
MALT1
MAP3K1
MAPKBP1
MKRN2
NAA10
NDUFAF3
NEDD4
NR1I2
OTUB2
OTUD6A
PAN2
PCGF2
PRKCA
PRKN
PSMA1
PSMD4
RNF181
RNF31
SMURF1
SOCS6
SYCE1
TNFAIP3
TP53
TRAF1
TRIM21
TRIM25
TRIM65
TRIML1
TSSK3
TTC23
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2G1
UBE2K
UBE2L3
UBE2L6
UBE2N
UBE2S
UBE2U
UCHL5
UHRF2
USP15
USP2
USP21
USP32
USP49
USP7
ZNF414
32 interacting genes:
ACTN2
ATP6AP1
CHMP1A
DNMT3L
DYRK2
EP300
FGR
HNF4A
MAPK7
NCOA1
NCOA2
NCOA3
NCOA6
NCOR2
NFATC4
NR0B2
NR5A2
NUCB2
POU1F1
PPARGC1A
PSMC5
RBCK1
RPS6KB1
RXRA
RXRB
RXRG
SDF4
SRC
TADA3
TFAP2C
UBE2I
UBR5
Entrez ID
10616
8856
HPRD ID
16643
04346
Ensembl ID
ENSG00000125826
ENSG00000144852
Uniprot IDs
A6PVJ6
A6PVK0
Q9BYM8
F1D8P9
O75469
PDB IDs
2CRC
2LGY
4DBG
1ILG
1ILH
1M13
1NRL
1SKX
2O9I
2QNV
3CTB
3HVL
3R8D
4J5W
4J5X
4NY9
4S0S
4S0T
4X1F
4X1G
4XAO
4XHD
5A86
5X0R
6BNS
6DUP
6HJ2
6HTY
6NX1
6P2B
6S41
6XP9
Enriched GO Terms of Interacting Partners
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