PAICS and NIF3L1

Data Source:
BioGRID (two hybrid)

		PAICS	NIF3L1
Description		phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	NGG1 interacting factor 3 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Identical Protein Binding 5-amino-4-imidazole Carboxylate Lyase Activity Cadherin Binding	Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process	Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Purine ribonucleoside monophosphate biosynthesis
Drugs		Aspartic acid
Diseases
GWAS			Triptolide cytotoxicity ( 26121980)
Interacting Genes		18 interacting genes: CDC37 CEP76 CHD3 FXR2 L3MBTL2 LNX1 MOB4 NIF3L1 NUDT18 PIAS2 PILRA PRKAG1 RAD54L2 RNF4 SMARCD1 TERF1 UBE2I ZMYM2	93 interacting genes: ALKBH4 AP5B1 APIP ARPIN BDKRB2 BEND7 C14orf119 CASP7 CCDC102B CCDC85B CDKN2B CDKN2C CDKN2D COIL COPS2 CUTC CYRIB DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DTX2 DUSP23 DUSP29 DYNLT3 EIF4A3 EIF5A2 ENOX1 EPHB6 FLAD1 FXR2 GNMT GRB2 IP6K3 KCNIP1 KCTD17 KCTD7 KCTD9 KRT15 KXD1 LAMTOR3 LMO2 LMO3 MAGEA11 MAPRE2 MLXIPL NATD1 NEK6 NGB NME1 NME7 NOL3 NUDT14 NUDT21 ORC5 PAFAH1B3 PAICS PCBD1 PNMA1 POLR1C PPIH PRTFDC1 PTPA RABAC1 RAD54B RPIA S100A1 SAT1 SEPTIN1 SNF8 SPG21 SSX2IP STAT3 STK16 SULT1A2 SULT1A3 SULT2A1 SYT17 TCL1A THOC7 TIFA TRAF2 TRIM21 TRIM27 TRIP13 TSC22D4 TXN VIM YES1 YWHAQ ZBED1
Entrez ID		10606	60491
HPRD ID		01401	10424
Ensembl ID		ENSG00000128050	ENSG00000196290
Uniprot IDs		P22234	A0A024R3V5 A0A024R3V7 Q9GZT8
PDB IDs		2H31 6YB8 6YB9
Enriched GO Terms of Interacting Partners?
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