POMT1 and POMT2

Data Source:
HPRD (in vitro, in vivo)

		POMT1	POMT2
Description		protein O-mannosyltransferase 1	protein O-mannosyltransferase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Sarcoplasmic Reticulum	Nucleoplasm Nucleolus Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane
	Molecular Function	Mannosyltransferase Activity Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Metal Ion Binding	Mannosyltransferase Activity Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Protein O-linked Glycosylation Multicellular Organism Development Extracellular Matrix Organization Protein O-linked Mannosylation Positive Regulation Of Protein O-linked Glycosylation	Protein O-linked Glycosylation Protein O-linked Mannosylation ER-associated Misfolded Protein Catabolic Process Positive Regulation Of Protein O-linked Glycosylation
Pathways		Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 O-linked glycosylation	Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 O-linked glycosylation
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Dystroglycanopathy; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama congenital muscular dystrophy (FCMD); Congenital muscular dystrophy with muscle hypertrophy (MDC1C); Congenital muscular dystrophy with severe intellectual impairment and abnormal glycosylation (MDC1D) Limb-girdle muscular dystrophy (LGMD)	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Dystroglycanopathy; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama congenital muscular dystrophy (FCMD); Congenital muscular dystrophy with muscle hypertrophy (MDC1C); Congenital muscular dystrophy with severe intellectual impairment and abnormal glycosylation (MDC1D) Limb-girdle muscular dystrophy (LGMD)
GWAS
Interacting Genes		2 interacting genes: MEOX2 POMT2	3 interacting genes: GLP1R LINC00839 POMT1
Entrez ID		10585	29954
HPRD ID		06305	09592
Ensembl ID		ENSG00000130714	ENSG00000009830
Uniprot IDs		A0A140VKE0 Q9Y6A1	Q9UKY4
PDB IDs
Enriched GO Terms of Interacting Partners?
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