SIVA1 and CD27

Data Source:
HPRD (two hybrid, in vitro)

		SIVA1	CD27
Description		SIVA1 apoptosis inducing factor	CD27 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Metal Ion Binding	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Viral Entry Into Host Cell Extrinsic Apoptotic Signaling Pathway	Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways			TNFs bind their physiological receptors
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) Thyroid stimulating hormone levels ( 32769997)	Crohn's disease ( 26192919)
Interacting Genes		30 interacting genes: ABL2 APP AQP1 BCL2L1 BEX3 C2orf68 CATSPER1 CD27 CD4 CDKN2A CREB5 HOXA1 ING3 KRTAP26-1 MEFV NEDD4 NEDD4L NTAQ1 PCNA PM20D2 POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TFAP2D TNFRSF4 UBE2D1 ZNF446	8 interacting genes: ACTN2 CD70 CIB1 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2
Entrez ID		10572	939
HPRD ID		16124	01723
Ensembl ID		ENSG00000184990	ENSG00000139193
Uniprot IDs		O15304	P26842
PDB IDs			5TL5 5TLJ 5TLK
Enriched GO Terms of Interacting Partners?
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