TOMM40 and SAMM50

Data Source:
BioGRID (biochemical, pull down)

		TOMM40	SAMM50
Description		translocase of outer mitochondrial membrane 40	SAMM50 sorting and assembly machinery component
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Mitochondrial Inner Membrane Cytosol Integral Component Of Membrane Integral Component Of Mitochondrial Outer Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Pore Complex	SAM Complex Mitochondrion Mitochondrial Outer Membrane Integral Component Of Membrane Extracellular Exosome MIB Complex
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Porin Activity	Protein Binding
	Biological Process	Protein Targeting To Mitochondrion Macroautophagy Protein Import Into Mitochondrial Matrix	Inner Mitochondrial Membrane Organization Mitochondrial Respiratory Chain Complex Assembly Cellular Protein-containing Complex Assembly Cristae Formation Protein Insertion Into Mitochondrial Outer Membrane
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy	Mitochondrial protein import Cristae formation
Drugs
Diseases
GWAS		Age-related macular degeneration ( 22694956 23326517) Alzheimer's disease ( 22832961 24770881 30636644 18823527 19734902 29107063 24755620 19125160 20061627) Alzheimer's disease (age of onset) ( 29107063 22005931) Alzheimer's disease (late onset) ( 20885792 23565137 26339675) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease biomarkers ( 23562540 21123754 23419831) Alzheimer's disease in hypertension ( 31055733) Alzheimer's disease in hypertension-negative individuals ( 31055733) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat percentage ( 26833246) Body mass index ( 26426971 25673413) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain imaging ( 20100581) C-reactive protein ( 22939635) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebral amyloid deposition (PET imaging) ( 26252872 30361487) Cerebral amyloid deposition positivity (PET imaging) ( 26252872) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 28247064 30319691 28641921 29274321 20932310) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 30319691) Cerebrospinal fluid t-tau levels ( 28641921 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30319691 28641921) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Cholesterol, total ( 19060911) Cingulate cortical amyloid beta load ( 26421299) Cognitive decline ( 22054870 23207651) Cognitive decline (age-related) ( 28078323 24468470) Cognitive function ( 25644384) Cognitive impairment test score ( 30319691) Coronary artery disease ( 29212778) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) HDL cholesterol ( 21909109 19060911) Hippocampal atrophy rate ( 31760383) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lamb consumption ( 32066663) LDL cholesterol ( 26160806 19060911) LDL cholesterol levels ( 26763881) Lipid traits ( 24386095) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Longevity ( 21418511) Meat-related diet ( 32066663) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mental health study participation (completed survey) ( 31263887) Metabolic syndrome ( 22399527) Posterior cortical atrophy and Alzheimer's disease ( 26993346) Quantitative traits ( 19197348) Refractive error ( 32231278) Sense of smell ( 26632684) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglycerides ( 19060911) Type 2 diabetes ( 27189021 30297969) Verbal declarative memory ( 25648963) Verbal memory performance (immediate recall change) ( 28800603) Verbal memory performance (residualized delayed recall level) ( 28800603) Waist circumference ( 25673412) Waist-hip ratio ( 25673412)	Alanine aminotransferase levels ( 30718733) Cholesterol, total ( 26780889) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Metabolite levels ( 23823483) Nonalcoholic fatty liver disease ( 22719876 29271184 29385134) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Total cholesterol levels ( 28334899) Type 2 diabetes ( 30054458)
Interacting Genes		8 interacting genes: HSD17B10 HSP90AA1 HSPA4 MTX1 PRKN SAMM50 TOMM20 TOMM7	5 interacting genes: CHCHD3 CHCHD6 HMGB2 MEOX2 TOMM40
Entrez ID		10452	25813
HPRD ID		16274	10826
Ensembl ID		ENSG00000130204	ENSG00000100347
Uniprot IDs		O96008	Q9Y512
PDB IDs		7CK6
Enriched GO Terms of Interacting Partners?
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