ABCA7 and C5AR2

Data Source:
BioGRID (two hybrid)

		ABCA7	C5AR2
Description		ATP binding cassette subfamily A member 7	complement component 5a receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Phagocytic Cup Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Early Endosome Membrane Ruffle Membrane Intracellular Membrane-bounded Organelle Glial Cell Projection	Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell
	Molecular Function	Lipid Transporter Activity ATP Binding Phospholipid Transporter Activity ATPase Activity Apolipoprotein A-I Receptor Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Phosphatidylserine Floppase Activity Floppase Activity	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Lipid Transport Phagocytosis Memory Visual Learning Positive Regulation Of Cholesterol Efflux Peptide Cross-linking Regulation Of Lipid Metabolic Process Cholesterol Efflux Phospholipid Efflux Amyloid-beta Formation High-density Lipoprotein Particle Assembly Protein Localization To Nucleus Apolipoprotein A-I-mediated Signaling Pathway Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of MAPK Cascade Plasma Membrane Raft Organization Phospholipid Translocation Negative Regulation Of Endocytosis Positive Regulation Of Phagocytosis Transmembrane Transport Positive Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Engulfment Of Apoptotic Cell Negative Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Phospholipid Efflux Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Protein Localization To Cell Surface	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Complement Activation Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis
Pathways		ABC transporters in lipid homeostasis	Peptide ligand-binding receptors Regulation of Complement cascade
Drugs
Diseases
GWAS		Alzheimer's disease ( 21460840 31473137) Alzheimer's disease (late onset) ( 21460841 23571587 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Eosinophil percentage of white cells ( 27863252) Family history of Alzheimer's disease ( 30617256) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 31628463) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)
Interacting Genes		2 interacting genes: ADRB2 C5AR2	17 interacting genes: ABCA7 ACO2 C3 C4A C4orf3 C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234
Entrez ID		10347	27202
HPRD ID		09255	17072
Ensembl ID		ENSG00000064687	ENSG00000134830
Uniprot IDs		B3KUJ3 Q8IZY2	Q9P296
PDB IDs
Enriched GO Terms of Interacting Partners?
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