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TLR6 and HRAS
Data Source:
BioGRID
(pull down)
TLR6
HRAS
Description
toll like receptor 6
HRas proto-oncogene, GTPase
Image
GO Annotations
Cellular Component
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Phagocytic Vesicle Membrane
Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex
Receptor Complex
Membrane Raft
Golgi Membrane
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Molecular Function
Amyloid-beta Binding
Transmembrane Signaling Receptor Activity
Signaling Receptor Binding
Protein Binding
Toll-like Receptor 2 Binding
Signaling Receptor Activity
Identical Protein Binding
Protein Heterodimerization Activity
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Lipopeptide Binding
GTPase Activity
Protein Binding
GTP Binding
Protein C-terminus Binding
GDP Binding
Protein-containing Complex Binding
Biological Process
Microglial Cell Activation
Cell Activation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Immune Response
Signal Transduction
Activation Of NF-kappaB-inducing Kinase Activity
Positive Regulation Of Gene Expression
Interleukin-1 Beta Production
Negative Regulation Of Interleukin-8 Production
Positive Regulation Of Interleukin-6 Production
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 6 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Detection Of Diacyl Bacterial Lipopeptide
Defense Response To Bacterium
Positive Regulation Of Macrophage Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JUN Kinase Activity
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Nitric Oxide Metabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Bacterial Lipopeptide
Cellular Response To Diacyl Bacterial Lipopeptide
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Oxidative Stress-induced Neuron Death
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
MAPK Cascade
Liver Development
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Endocytosis
Chemotaxis
Cell Cycle Arrest
Signal Transduction
Cell Surface Receptor Signaling Pathway
Ras Protein Signal Transduction
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Animal Organ Morphogenesis
Negative Regulation Of Gene Expression
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Cell Migration
Positive Regulation Of Interferon-gamma Production
Negative Regulation Of GTPase Activity
Response To Isolation Stress
T-helper 1 Type Immune Response
Defense Response To Protozoan
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of DNA Replication
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Ras Protein Signal Transduction
Ephrin Receptor Signaling Pathway
Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Epithelial Cell Proliferation
T Cell Receptor Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Gamma Radiation
Positive Regulation Of Wound Healing
Positive Regulation Of Protein Targeting To Membrane
Cellular Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Positive Regulation Of Ruffle Assembly
Positive Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of MiRNA Metabolic Process
Pathways
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
SOS-mediated signalling
Activation of RAS in B cells
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Signalling to RAS
p38MAPK events
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
EPHB-mediated forward signaling
Ras activation upon Ca2+ influx through NMDA receptor
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
RAS signaling downstream of NF1 loss-of-function variants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Insulin receptor signalling cascade
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Estrogen-stimulated signaling through PRKCZ
RAS processing
RAS GTPase cycle mutants
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Drugs
Hexane-1,6-Diol
Trifluoroethanol
Guanosine-5'-Triphosphate
Guanosine-5'-Diphosphate
N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE
Diseases
Bladder cancer
Penile cancer
Squamous cell carcinoma
Thyroid cancer
Cervical cancer
Hepatocellular carcinoma
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Allergic sensitization (
30013184
23817571
)
Allergy (
27182965
)
Asthma (
31959851
)
Asthma (age of onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) (
27670767
)
Helicobacter pylori serologic status (
23652523
)
Self-reported allergy (
23817569
)
Interacting Genes
4 interacting genes:
BTK
HRAS
TLR2
TRAP1
146 interacting genes:
ABR
ACTG1
AFDN
AGTR1
ANAPC1
ANKRD11
ANKRD16
ANKRD23
ANKRD34B
APBB1IP
ARAF
ARFGAP1
ARHGAP10
ARHGAP29
ARHGEF1
ARHGEF18
BCL2
BLID
BMPR1A
BRAF
BRAP
BUB1
CAV1
CDC123
CDC25A
CDC25C
CDH1
CDKN2A
CTNNA1
CXCL1
DEAF1
DGKE
DGKZ
DPP9
EIF3L
ERBB2
FBXW7
FNTA
FNTB
FYN
GPSM2
GPSM3
GRB2
GREB1
GRIN1
GRIN2D
HECTD1
HSPA12A
HSPA1L
ICMT
IKZF3
IL1RL1
IL24
IL3
INSR
IRAK1
IRAK2
ITGB3
ITSN1
KRAS
KRT17
KRT18
LGALS1
LZTR1
MAP2K1
MAP2K6
MAP3K6
MAPK10
MAPK8
MLH3
MSH2
MSH6
MTOR
MUTYH
NF1
NRAS
PDE4D
PDE6D
PDGFB
PDGFRL
PI4K2A
PIK3CA
PIK3CD
PIK3CG
PIK3R1
PLA2G4B
PLAAT4
PLCE1
PLCH2
PRKCI
PRKCZ
PRSS50
PTPRJ
QPCT
RAB5C
RABAC1
RABGEF1
RAF1
RALGDS
RAP1B
RAP1GDS1
RAPGEF1
RASA1
RASA2
RASA4
RASGRF1
RASGRP1
RASGRP4
RASIP1
RASSF1
RASSF2
RASSF5
RGL1
RGL2
RGL4
RGS12
RHOD
RIN1
RIT2
RNF115
RSPO3
SHOC2
SMAD4
SNRPE
SNX14
SNX17
SOS1
SOS2
SRC
STK11
STK38
TIAM1
TLR2
TLR6
TLR9
TP73
TTC1
TTC21A
TTC28
UBE3B
UBE4B
USP29
USP42
VAV1
ZBTB10
ZBTB12
Entrez ID
10333
3265
HPRD ID
05656
01813
Ensembl ID
ENSG00000174130
ENSG00000174775
Uniprot IDs
B2R933
Q9Y2C9
P01112
X5D945
PDB IDs
4OM7
121P
1AA9
1AGP
1BKD
1CLU
1CRP
1CRQ
1CRR
1CTQ
1GNP
1GNQ
1GNR
1HE8
1IAQ
1IOZ
1JAH
1JAI
1K8R
1LF0
1LF5
1LFD
1NVU
1NVV
1NVW
1NVX
1P2S
1P2T
1P2U
1P2V
1PLJ
1PLK
1PLL
1Q21
1QRA
1RVD
1WQ1
1XCM
1XD2
1XJ0
1ZVQ
1ZW6
221P
2C5L
2CE2
2CL0
2CL6
2CL7
2CLC
2CLD
2EVW
2GDP
2LCF
2LWI
2N42
2N46
2Q21
2QUZ
2RGA
2RGB
2RGC
2RGD
2RGE
2RGG
2UZI
2VH5
2X1V
3DDC
3I3S
3K8Y
3K9L
3K9N
3KKM
3KKN
3KUD
3L8Y
3L8Z
3LBH
3LBI
3LBN
3LO5
3OIU
3OIV
3OIW
3RRY
3RRZ
3RS0
3RS2
3RS3
3RS4
3RS5
3RS7
3RSL
3RSO
3TGP
421P
4DLR
4DLS
4DLT
4DLU
4DLV
4DLW
4DLX
4DLY
4DLZ
4DST
4DSU
4EFL
4EFM
4EFN
4G0N
4G3X
4K81
4L9S
4L9W
4NYI
4NYJ
4NYM
4Q21
4RSG
4URU
4URV
4URW
4URX
4URY
4URZ
4US0
4US1
4US2
4XVQ
4XVR
521P
5B2Z
5B30
5E95
5P21
5VBE
5VBZ
5WDO
5WDP
5WDQ
5WFO
5WFP
5WFQ
5WFR
5WPL
5X9S
5ZC6
621P
6AMB
6AXG
6BVI
6BVJ
6BVK
6BVL
6BVM
6CUO
6CUP
6CUR
6D55
6D56
6D59
6D5E
6D5G
6D5H
6D5J
6D5L
6D5M
6D5V
6D5W
6DZH
6E6C
6E6P
6MQT
6NTC
6NTD
6Q21
6V94
6V9F
6V9J
6V9L
6V9M
6V9N
6ZJ0
6ZL3
721P
7JHP
821P
Enriched GO Terms of Interacting Partners
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