RXYLT1 and POMGNT1

Data Source:
BioGRID (two hybrid)

		RXYLT1	POMGNT1
Description		ribitol xylosyltransferase 1	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Golgi Apparatus Integral Component Of Plasma Membrane	Golgi Membrane Integral Component Of Membrane Integral Component Of Golgi Membrane
	Molecular Function	Protein Binding Ribitol Beta-1,4-xylosyltransferase Activity	Protein Binding Acetylglucosaminyltransferase Activity Manganese Ion Binding Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity
	Biological Process	Protein O-linked Mannosylation	Protein O-linked Glycosylation O-glycan Processing Protein Phosphopantetheinylation
Pathways			Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 O-linked glycosylation
Drugs
Diseases			Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Dystroglycanopathy; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama congenital muscular dystrophy (FCMD); Congenital muscular dystrophy with muscle hypertrophy (MDC1C); Congenital muscular dystrophy with severe intellectual impairment and abnormal glycosylation (MDC1D) Limb-girdle muscular dystrophy (LGMD)
GWAS			Body mass index ( 26426971)
Interacting Genes		2 interacting genes: GPR3 POMGNT1	11 interacting genes: BRCA1 CD74 CISD2 CXCL8 CXorf66 ERGIC3 LNX1 RXYLT1 SOX6 TMEM237 ZBTB18
Entrez ID		10329	55624
HPRD ID		12057	09493
Ensembl ID		ENSG00000118600	ENSG00000085998
Uniprot IDs		G3V1K2 Q9Y2B1	B7Z7F2 B7Z7Q4 Q8WZA1
PDB IDs			5GGF 5GGG 5GGI 5GGJ 5GGK 5GGL 5GGN 5GGO 5GGP 5XFC
Enriched GO Terms of Interacting Partners?
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