BCKDK and BCKDHB

Data Source:
BioGRID (proximity labelling technology)

		BCKDK	BCKDHB
Description		branched chain keto acid dehydrogenase kinase	branched chain keto acid dehydrogenase E1 subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex	Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity	Alpha-ketoacid Dehydrogenase Activity 3-methyl-2-oxobutanoate Dehydrogenase (2-methylpropanoyl-transferring) Activity Protein Binding
	Biological Process	Protein Phosphorylation Cellular Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Regulation Of Glucose Metabolic Process Phosphorylation	Response To Nutrient Branched-chain Amino Acid Catabolic Process
Pathways		Branched-chain amino acid catabolism	Glyoxylate metabolism and glycine degradation Branched-chain amino acid catabolism
Drugs		Adenosine 5'-[gamma-thio]triphosphate
Diseases			Maple syrup urine disease (MSUD)
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498)	Adolescent idiopathic scoliosis ( 31417091) Diastolic blood pressure ( 30224653) Height ( 28552196 25282103 23563607 31562340) Joint mobility (Beighton score) ( 27182965) Protein level change in low calorie diet obesity intervention ( 29234017) Prudent dietary pattern ( 28644415) Sitting height ratio ( 25865494) Spine bone size ( 31053729) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		8 interacting genes: APP EPS8 FBXO7 LSM8 NR5A2 SPTA1 STAT3 TRAF4	1 interacting genes: BCKDHA
Entrez ID		10295	594
HPRD ID		12523	02011
Ensembl ID		ENSG00000103507	ENSG00000083123
Uniprot IDs		A0A024QZA9 O14874	A0A140VKB3 B4E2N3 B7ZB80 P21953
PDB IDs			1DTW 1OLS 1OLU 1OLX 1U5B 1V11 1V16 1V1M 1V1R 1WCI 1X7W 1X7X 1X7Y 1X7Z 1X80 2BEU 2BEV 2BEW 2BFB 2BFC 2BFD 2BFE 2BFF 2J9F
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?