RABEPK and PIKFYVE

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RABEPK	PIKFYVE
Description		Rab9 effector protein with kelch motifs	phosphoinositide kinase, FYVE-type zinc finger containing
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Endosome Membrane Transport Vesicle Trans-Golgi Network Membrane	Golgi Membrane Cytosol Cell-cell Junction Endosome Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	1-phosphatidylinositol-3-phosphate 5-kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity 1-phosphatidylinositol-5-kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Receptor-mediated Endocytosis Vesicle Docking Involved In Exocytosis	Protein Targeting To Membrane Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neutrophil Chemotaxis Myelin Assembly Melanosome Organization Protein Localization To Nucleus Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Peptidyl-serine Autophosphorylation Retrograde Transport, Endosome To Golgi Phosphatidylinositol Phosphorylation Phagosome Maturation Phagosome-lysosome Fusion 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Phosphatidylinositol 5-phosphate Metabolic Process Regulation Of Autophagosome Assembly
Pathways		Retrograde transport at the Trans-Golgi-Network	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases			Fleck corneal dystrophy (FCD); Francois-Neetens speckled corneal dystrophy
GWAS		Refractive error ( 32231278)	Adult asthma ( 27611488) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		8 interacting genes: GLUL PIKFYVE POR PRKRA RAB9A TMEM98 TRIM55 ZYX	6 interacting genes: APP CDK5 H3C1 MIR140 RABEPK VAC14
Entrez ID		10244	200576
HPRD ID		09337	17852
Ensembl ID		ENSG00000136933	ENSG00000115020
Uniprot IDs		A0A024R8A0 A0A0S2Z4Z1 A0A0S2Z4Z5 Q7Z6M1	Q9Y2I7
PDB IDs			7K2V
Enriched GO Terms of Interacting Partners?
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