DCAF7 and LIG1

Data Source:
BioGRID (enzymatic study)

		DCAF7	LIG1
Description		DDB1 and CUL4 associated factor 7	DNA ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Nuclear Body Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity ATP Binding Metal Ion Binding
	Biological Process	Multicellular Organism Development Protein Ubiquitination Post-translational Protein Modification	DNA Ligation Lagging Strand Elongation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Anatomical Structure Morphogenesis V(D)J Recombination Cell Division DNA Biosynthetic Process Okazaki Fragment Processing Involved In Mitotic DNA Replication
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation	POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand
Drugs			Bleomycin
Diseases			DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Interacting Genes		7 interacting genes: APP ATP13A2 BMPR1B DYRK1B LIG1 PWP2 YWHAG	12 interacting genes: CSNK2A1 DCAF7 EHMT1 EHMT2 HSPB1 INPP1 MRE11 PCNA PRKCB RGS2 TUBB3 UHRF1
Entrez ID		10238	3978
HPRD ID		09340	00534
Ensembl ID		ENSG00000136485	ENSG00000105486
Uniprot IDs		P61962	B4DM52 F5GZ28 P18858
PDB IDs			1X9N 5YY9 6P09 6P0A 6P0B 6P0C 6P0D 6P0E 6Q1V
Enriched GO Terms of Interacting Partners?
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