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TOPORS and MTDH
Data Source:
BioGRID
(pull down)
TOPORS
MTDH
Description
TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
metadherin
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Spindle Pole
Gamma-tubulin Complex
Nucleus
Nucleoplasm
Centriole
Cytoplasmic Dynein Complex
PML Body
Nuclear Speck
Midbody
Photoreceptor Connecting Cilium
Ciliary Basal Body
Fibrillar Center
Nucleus
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Bicellular Tight Junction
Integral Component Of Membrane
Apical Plasma Membrane
Nuclear Body
Nuclear Membrane
Intercellular Canaliculus
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
Antigen Binding
Ubiquitin-protein Transferase Activity
Protein Binding
SUMO Transferase Activity
DNA Topoisomerase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase II Transcription Factor Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
RNA Binding
Double-stranded RNA Binding
Protein Binding
NF-kappaB Binding
Biological Process
Protein Polyubiquitination
Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Retina Layer Formation
Protein Sumoylation
Protein Localization To Nucleus
Photoreceptor Cell Outer Segment Organization
Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Retinal Rod Cell Development
Retinal Cone Cell Development
Positive Regulation Of Ubiquitin-protein Transferase Activity
Maintenance Of Protein Location In Nucleus
Protein K48-linked Ubiquitination
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Autophagy
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Kinase B Signaling
Bicellular Tight Junction Assembly
Pathways
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of immune response proteins
Drugs
Diseases
Retinitis pigmentosa (RP)
GWAS
Early spontaneous preterm birth (
31194736
)
Immune response to smallpox vaccine (IL-6) (
22610502
)
Metabolite levels (
23823483
)
Mean corpuscular hemoglobin (
29403010
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
)
Migraine (
20802479
)
Nicotine metabolite ratio in current smokers (
27488534
)
Plasma parathyroid hormone levels (
30134803
)
Red cell distribution width (
32888494
27863252
28957414
)
Sweet taste preference (
32572145
)
Interacting Genes
28 interacting genes:
CASP8
CREBBP
EPM2A
H2AX
HABP4
MTDH
NKX3-1
SATB1
SERBP1
SIN3A
SNIP1
SPOP
SUMO1
SUMO2
TOP1
TP53
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2I
UBE2J1
UBE2L6
UBE2N
UBE2W
XRCC1
175 interacting genes:
ABCA12
ABCC3
ABTB1
ACTN1
ADCK2
ADGRA2
AGAP3
ALOX5
ANKRD13D
ANKRD26P1
ANPEP
ARNT2
ARRDC1
AXL
BCAS3
BCS1L
CAPN2
CARD8
CCL20
CCN2
CCNDBP1
CCT4
CD109
CD22
CDC14B
CDC42
CENPJ
CEP162
CLCN7
CLDN2
CLMN
COL13A1
COL4A4
COL6A1
CPT2
CRIM1
CSNK2A1
CTSB
CUL7
CUL9
CYFIP2
CYP27A1
CYP4V2
DMTF1
DNAH5
DNAI4
DOCK2
DOP1B
DSP
DUSP5
ECE1
EGFR
EGR1
ELN
EML1
EPHB1
EPHX2
ERCC2
ERICH6B
ESAM
FAM184A
FANCI
FASN
FCGRT
FLNA
FLNC
FN1
GHDC
GLG1
GRID1
HACE1
HERC5
HP1BP3
HSPG2
ICA1L
IFT46
IKBKB
IL17RA
IL2RB
IPO9
IRS2
ITGB5
ITPR3
JADE3
JAG1
KCNH1
KCNQ5
KDM6A
KMT2B
LAMA5
LDLRAD2
LOXL4
LRIG3
LRP1
LRP5
MAP3K12
MCM6
MEGF11
METTL3
MLPH
MMP2
MNT
MRC2
MRPL39
MYH9
MYL5
NEB
NEO1
NFKB2
NOTCH3
NPC1
NPR1
NUP210
NXF4
OBSCN
OGT
OR8G5
OSMR
PCCB
PCDH7
PDCD11
PKN1
PLAT
PLD2
PLEC
PLEKHO2
PLXNA3
PPFIA2
PRICKLE4
PSIP1
PTHLH
PWP2
RAB24
RGS13
RIN1
RIPK1
RNF123
RNF213
RSPO3
RYR1
SDK1
SELENOI
SEZ6L2
SGSM2
SH2B2
SIAE
SLC22A18AS
SLC38A4
SPEF2
SPRED2
SPTBN5
SQSTM1
SSH3
STEAP3
STK25
STXBP1
SYNE1
TACR2
TBC1D2B
TBCD
TCIRG1
TEP1
THBS1
THSD4
TINAGL1
TNS2
TOPORS
TRAPPC12
TRPC4AP
TUBB3
VIM
WDFY2
WNK2
ZNF559
ZXDC
Entrez ID
10210
92140
HPRD ID
11642
17459
Ensembl ID
ENSG00000197579
ENSG00000147649
Uniprot IDs
Q9NS56
A0A024R9D2
Q86UE4
PDB IDs
4QMG
Enriched GO Terms of Interacting Partners
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