Description |
cyclin dependent kinase 6 |
Raf-1 proto-oncogene, serine/threonine kinase |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
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- Asthma ( 32296059)
- Cardiac hypertrophy ( 21348951)
- Carotid intima media thickness x smoking interaction ( 32117412)
- Cholesterol, total ( 24097068 20686565)
- Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
- HDL cholesterol levels ( 32203549)
- Total cholesterol levels ( 28334899)
- Waist-to-hip ratio adjusted for BMI ( 26426971)
- Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
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Interacting Genes |
136 interacting genes:
ABI2
AKT1
ANKRD12
APOBEC1
AR
ARAF
ARNT
ATF6B
ATXN1
BCL11A
BECN1
CASC3
CBLC
CBY1
CCND1
CCND2
CCND3
CCNE1
CCNH
CCNI
CD44
CDC37
CDC6
CDK4
CDK7
CDKN1A
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CLASRP
CNOT7
CTNNB1
DDIT3
DEDD2
EBF4
EIF4ENIF1
ELK1
ELOA2
EPHA2
ERBB2
EZH2
FGFR4
FOXM1
FOXO3
FZR1
GLIS1
GLIS2
GRM1
H1-1
HGF
HIF1A
HSF1
ISL1
KAT2A
KDELR2
KEAP1
KIF26B
KLF10
LATS2
LPIN1
MAP2K3
MAP2K5
MAP3K5
MAPK14
MCM10
MCM2
MEF2D
MET
MLLT3
MSL3
MYC
MZF1
N4BP1
NF2
NFATC3
NIPBL
NUMA1
OTP
PCNA
PDGFRA
PML
POGZ
PPARGC1A
PPHLN1
PPM1B
PPP2CA
PRX
PSMA3
RAF1
RASSF1
RB1
RBL1
RBL2
RBM23
RBPMS
RUNX1
SENP3
SIRT1
SLBP
SNIP1
SORBS1
SOX10
SOX5
SRSF1
SRSF11
SRSF12
SRSF2
SRSF7
SSBP2
STK11
SUMO1
SYNPO2
TEAD2
TERT
TFDP1
TGFBR1
TJP2
TNFRSF1A
TP53
TPX2
TRA2A
TRA2B
TRAK1
TRIM15
TSC1
UHRF2
USP17L2
VGLL4
ZEB1
ZFP36
ZMYM3
ZNF101
ZNF174
ZNF335
ZSCAN1
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160 interacting genes:
ABCB5
ADCY6
AGTR1
AKT1
AR
ARNT
ARRB2
BAD
BAG1
BCL2
BCL2L1
BCL6
BECN1
BIRC2
BIRC3
BRAF
CASZ1
CBLC
CCND2
CCT3
CD44
CDC25A
CDC37
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CFLAR
CNKSR1
COPS3
COPS7A
CPS1
DCAF8
DMPK
EFEMP1
EGFR
EPHA2
ERBB2
ERBIN
FGFR4
FYCO1
FYN
GLIS2
GNB2
GNG4
GRB10
GRM1
HERC1
HGF
HRAS
HSP90AA1
HSPA4
HSPA8
IL2RB
INSR
INTS10
JAK1
JAK2
KEAP1
KRAS
KRT18
KRT8
KSR1
KSR2
LATS2
LCK
LOX
LRPAP1
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MAP2K6
MAP3K1
MAP3K5
MAPK1
MAPK3
MAPK7
MAPK8
MAPK8IP3
MBP
MET
MRAS
MRC2
MYBPC1
MYC
NEDD4
NF1
NF2
NPLOC4
NR3C1
NRAS
NUDT14
OIP5
PACSIN3
PAK1
PAK2
PAK3
PBK
PDGFRA
PDGFRB
PDLIM2
PEBP1
PEBP4
PEX5L
PHB
PHKA2
PIN1
PKM
PPP1CC
PPP2CB
PRKAA1
PRKACA
PRKAR1A
PRKCA
PRKCD
PRKCE
PRKCZ
PRKG1
PRPF6
PURA
RANBP9
RAP1A
RAP2A
RASD2
RASSF1
RB1
RBBP8
RBL2
RFXANK
RHEB
RRAS
RRAS2
RSU1
SHOC2
SPRY2
SPRY4
SRC
STK26
STK3
STUB1
TBXA2R
TEAD2
TERT
TIMM50
TMEM70
TSC22D3
UBE2D2
UBE2L3
VAV1
VDAC1
XIAP
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
YY1
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Entrez ID |
1021 |
5894 |
HPRD ID |
04533 |
01265 |
Ensembl ID |
ENSG00000105810
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ENSG00000132155
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Uniprot IDs |
Q00534
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A0A0S2Z4L5
L7RRS6
P04049
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PDB IDs |
1BI7
1BI8
1BLX
1G3N
1JOW
1XO2
2EUF
2F2C
3NUP
3NUX
4AUA
4EZ5
4TTH
5L2I
5L2S
5L2T
6OQL
6OQO
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1C1Y
1FAQ
1FAR
1GUA
1RFA
3CU8
3IQJ
3IQU
3IQV
3KUC
3KUD
3NKX
3O8I
3OMV
4FJ3
4G0N
4G3X
4IEA
4IHL
6NTC
6NTD
6PTS
6PTW
7JHP
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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