ARPC2 and CORO1B

Data Source:
HPRD (in vivo, in vitro)

		ARPC2	CORO1B
Description		actin related protein 2/3 complex subunit 2	coronin 1B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Lamellipodium Site Of Double-strand Break Muscle Cell Projection Membrane Neuron Projection Extracellular Exosome Glutamatergic Synapse	Stress Fiber Cytoplasm Cytosol Actin Filament Plasma Membrane Focal Adhesion Lamellipodium Cell Leading Edge Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Protein Binding Identical Protein Binding Cadherin Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Actin Filament Organization Cell Migration Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Endothelial Cell Chemotaxis Cellular Response To Platelet-derived Growth Factor Stimulus Wound Healing Actin Filament Bundle Assembly Negative Regulation Of Smooth Muscle Cell Chemotaxis Actin Filament Branching Protein Localization To Cell Leading Edge Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Inflammatory bowel disease ( 28067908 23128233) Mean platelet volume ( 32888494 27863252) Neutrophil count ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) White blood cell count ( 25096241 29403010)	HDL cholesterol levels ( 32203549) Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: ACTR3 ARPC1B ARPC4 AURKA CORO1B WAS	8 interacting genes: ARPC2 KPNA2 LHX4 POLR1C PRKCA SSH1 TERF1 TRIM15
Entrez ID		10109	57175
HPRD ID		10367	16743
Ensembl ID		ENSG00000163466	ENSG00000172725
Uniprot IDs		A0A024R408 O15144 Q53R19	A0A024R5K1 Q9BR76
PDB IDs		6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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