CTDSP2 and TYRO3

Data Source:
BioGRID (two hybrid)

		CTDSP2	TYRO3
Description		CTD small phosphatase 2	TYRO3 protein tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleoplasm	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Virus Receptor Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation IRE1-mediated Unfolded Protein Response Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Natural Killer Cell Differentiation Phagocytosis Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organism Development Spermatogenesis Nervous System Development Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Secretion By Cell Positive Regulation Of Kinase Activity Negative Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Innate Immune Response Viral Entry Into Host Cell Protein Autophosphorylation Negative Regulation Of Inflammatory Response Negative Regulation Of Lymphocyte Activation Vagina Development Neuron Cellular Homeostasis Platelet Aggregation Positive Regulation Of Viral Life Cycle
Pathways		XBP1(S) activates chaperone genes
Drugs			Fostamatinib
Diseases
GWAS		Height ( 31562340) Hematocrit ( 32888494) Metabolite levels ( 23823483) Refractive error ( 32231278) Trochanter size ( 31053729)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Microalbuminuria ( 31511532) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		13 interacting genes: AKT1 AR CDCA3 CSF1R EPHA1 EPHA3 INSRR LCN2 N4BP3 POLR2A PTK7 SNAI1 TYRO3	28 interacting genes: A2M APOE AXL CTDSP1 CTDSP2 ERBB2 FYN GAS6 GRB2 IKBKG KLK4 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 LNX1 MDFI MGAT5B PIK3R1 PROS1 SRC TNIP1 VWC2L YES1
Entrez ID		10106	7301
HPRD ID		12281	02641
Ensembl ID		ENSG00000175215	ENSG00000092445
Uniprot IDs		A0A024RB65 A0A024RBA6 O14595	H0YNK6 Q06418
PDB IDs		2Q5E	1RHF
Enriched GO Terms of Interacting Partners?
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