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PQBP1 and WDR77
Data Source:
BioGRID
(two hybrid)
PQBP1
WDR77
Description
polyglutamine binding protein 1
WD repeat domain 77
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytoplasmic Stress Granule
Nuclear Body
Nuclear Speck
Neuronal Ribonucleoprotein Granule
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Methylosome
Pole Plasm
Molecular Function
DNA Binding
Double-stranded DNA Binding
Transcription Coactivator Activity
Protein Binding
Ribonucleoprotein Complex Binding
Protein Binding
Methyl-CpG Binding
Nuclear Receptor Coactivator Activity
Biological Process
Alternative MRNA Splicing, Via Spliceosome
MRNA Splicing, Via Spliceosome
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Regulation Of Transcription, DNA-templated
Neuron Projection Development
Positive Regulation Of Type I Interferon Production
Regulation Of RNA Splicing
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Regulation Of Dendrite Morphogenesis
Defense Response To Virus
Cellular Response To Exogenous DsRNA
Spliceosomal SnRNP Assembly
Regulation Of Transcription By RNA Polymerase II
Pole Plasm Assembly
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Transcription, DNA-templated
Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways
mRNA Splicing - Major Pathway
snRNP Assembly
RMTs methylate histone arginines
Drugs
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
Non-syndromic X-linked mental retardation
GWAS
Interacting Genes
24 interacting genes:
APBB1
APP
AQR
ATXN1
CLTB
EEF1A1
ERG28
ESR1
GOLGA2
HNRNPH2
LNX1
LRIF1
LZTS2
MAPRE1
MED31
POLR2A
POU3F2
RAB8A
RCVRN
SFTPC
TLX3
TXNL4A
WBP11
WDR77
44 interacting genes:
AQR
BAG2
CDK19
CDK8
CLNS1A
CREBBP
CTDP1
GLI1
GPKOW
H2AC21
HNRNPM
LSM3
NKX3-1
PCBP2
PPIL1
PPP1R8
PQBP1
PRKG1
PRKG2
PRMT5
QKI
RBM5
RIOK1
SAP30BP
SF1
SF3A1
SF3B4
SIRT7
SMAD1
SMYD1
SNRPB
SNRPC
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNRPF
SUZ12
THOC1
TOE1
YWHAB
YWHAQ
ZMYND19
ZNF207
Entrez ID
10084
79084
HPRD ID
02354
14387
Ensembl ID
ENSG00000102103
ENSG00000116455
Uniprot IDs
A0A0S2Z4V5
O60828
A0A024R0H7
Q9BQA1
PDB IDs
4BWQ
4BWS
4CDO
4GQB
4X60
4X61
4X63
5C9Z
5EMJ
5EMK
5EML
5EMM
5FA5
6CKC
6K1S
6RLL
6RLQ
6UXX
6UXY
6V0N
6V0O
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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