DNM1L and MIEF2

Data Source:
BioGRID (pull down)

		DNM1L	MIEF2
Description		dynamin 1 like	mitochondrial elongation factor 2
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Peroxisome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Brush Border Clathrin-coated Pit Membrane Synaptic Vesicle Membrane Mitochondrial Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Presynaptic Endocytic Zone Membrane Mitochondrion-derived Vesicle	Mitochondrion Mitochondrial Outer Membrane Peroxisome Integral Component Of Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Microtubule Binding Lipid Binding Clathrin Binding GTP-dependent Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding BH2 Domain Binding	Protein Binding
	Biological Process	Mitochondrial Fission Release Of Cytochrome C From Mitochondria Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Calcium Ion Transport Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Gene Expression Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Peroxisome Fission Synaptic Vesicle Recycling Via Endosome Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Mitochondrial Fragmentation Involved In Apoptotic Process Intracellular Distribution Of Mitochondria Synaptic Vesicle Endocytosis Rhythmic Process Positive Regulation Of Protein Secretion Protein Complex Oligomerization Heart Contraction Positive Regulation Of Dendritic Spine Morphogenesis Membrane Fusion Protein-containing Complex Assembly Necroptotic Process Mitochondrion Morphogenesis Protein Localization To Mitochondrion Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Mitochondrial Fission Mitochondrial Membrane Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Oxygen-glucose Deprivation Execution Phase Of Apoptosis Regulation Of Peroxisome Organization Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Autophagy Of Mitochondrion Regulation Of ATP Metabolic Process Cellular Response To Thapsigargin Regulation Of Ubiquitin Protein Ligase Activity Response To Flavonoid Response To Hypobaric Hypoxia Positive Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Mitochondrion Organization Mitochondrial Fusion Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane
Pathways		Apoptotic execution phase
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494)	Change in neurofilament light levels ( 31295725)
Interacting Genes		20 interacting genes: FIS1 FZR1 GSK3B MAGEA1 MAGEA3 MAP3K10 MFF MIEF1 MIEF2 MUL1 PINK1 PRKN RRM2 SCG3 SENP3 SH3GL1 SIRT3 SUMO2 VIM ZBTB24	30 interacting genes: AGTRAP ARFIP2 ARL6IP1 ATP5PF CIDEA DNM1L FAM114A2 FAM25A FAM25C FAM25G FKBP7 GSG1 HSD17B13 LIME1 MDK NCALD NCS1 PRB2 PSMF1 RABAC1 REEP6 RHBDD2 SFT2D1 SYP TMEM239 UBQLN1 UBQLN2 UBQLN4 YIF1A ZNF628
Entrez ID		10059	125170
HPRD ID		04833	18074
Ensembl ID		ENSG00000087470	ENSG00000177427
Uniprot IDs		B4DYR6 O00429	Q96C03
PDB IDs		3W6N 3W6O 3W6P 4BEJ 4H1U 4H1V 5WP9	5WP9
Enriched GO Terms of Interacting Partners?
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