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SAE1 and SUMO1
Data Source:
BioGRID
(pull down)
SAE1
SUMO1
Description
SUMO1 activating enzyme subunit 1
small ubiquitin like modifier 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
SUMO Activating Enzyme Complex
Nucleus
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Nucleolus
Cytosol
Plasma Membrane
Voltage-gated Potassium Channel Complex
Nuclear Body
PML Body
Nuclear Speck
Nuclear Membrane
Nuclear Stress Granule
Molecular Function
Ubiquitin Activating Enzyme Activity
Protein Binding
Protein C-terminus Binding
Enzyme Activator Activity
SUMO Activating Enzyme Activity
ATP-dependent Protein Binding
Small Protein Activating Enzyme Binding
Protein Heterodimerization Activity
RNA Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Enzyme Binding
Protein Tag
Ubiquitin Protein Ligase Binding
Small Protein Activating Enzyme Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin-specific Protease Binding
Biological Process
Protein Ubiquitination
Protein Sumoylation
Protein Phosphopantetheinylation
Protein Modification By Small Protein Conjugation
Positive Regulation Of Protein Sumoylation
Regulation Of Catalytic Activity
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Transcription By RNA Polymerase II
DNA Repair
Double-strand Break Repair Via Nonhomologous End Joining
Viral Process
Protein Sumoylation
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Cellular Response To Heat
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Action Potential
Negative Regulation Of Transcription, DNA-templated
Protein Stabilization
Roof Of Mouth Development
Regulation Of Interferon-gamma-mediated Signaling Pathway
Cellular Response To Cadmium Ion
Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMO E3 ligases SUMOylate target proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
Regulation of IFNG signaling
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
Drugs
Diseases
GWAS
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Multiple sclerosis (
31604244
21833088
)
Multiple sclerosis and triglyceride levels (pleiotropy) (
26920376
)
Neutrophil percentage of white cells (
32888494
)
Red blood cell count (
32888494
)
White blood cell count (
32888494
27863252
)
Interacting Genes
22 interacting genes:
AGTR1
APP
CRX
ERCC6
ETV4
HSPA1A
HSPA2
IL3RA
MEOX2
NFYC
PAX5
PAX6
PAX8
PTK2
SUMO1
SUMO2
SUMO3
UBA2
UBD
UBE2E3
UBE2I
USP39
151 interacting genes:
AR
ATF2
ATXN1
ATXN3
ATXN7
AXIN1
BIRC3
BLM
BRCA1
BTBD3
C11orf65
C18orf25
CANX
CARD9
CASP2
CASP8
CCR2
CDK6
CHAF1A
CHD3
CREBBP
DAXX
DEUP1
DNM1
DNMT3B
DTX2
EDARADD
EGLN3
EIF2AK2
ERCC6
ETV6
FAF1
FAM118B
FAS
FASLG
FBF1
FOS
FOXM1
GMCL1
HDAC4
HDAC9
HGS
HIF1A
HIPK2
HIPK3
HNRNPC
HNRNPK
HSF1
HTT
IKZF3
IRAK1
JUN
MAPK1IP1L
MDM2
MEF2A
MITF
MRE11
MRTFA
MSX1
MTOR
MUL1
MYB
NCOA1
NCOA2
NCOA3
NCOR2
NFE2L2
NFKBIA
NIN
NR3C1
NR3C2
PARK7
PAX6
PCNA
PDGFC
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PKM
PLAGL1
PML
PPM1J
PRKN
PROP1
PSIP1
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RHOXF2
RNF111
RNF167
RNF4
RPS3
SAE1
SALL1
SATB1
SENP1
SENP2
SENP6
SETX
SLC2A1
SOX10
SOX2
SOX6
SP100
SP3
SPOP
SREBF1
SREBF2
SUMO1P1
TDG
TDP2
TFCP2
TMIE
TNFRSF1A
TOE1
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP73
TRAF2
TRAF4
TRAF5
TRIM24
TRPS1
TSC22D3
UBA2
UBE2I
USP25
USPL1
WRN
XPO1
ZBTB16
ZBTB2
ZBTB26
ZBTB6
ZCCHC12
ZCCHC7
ZFP42
ZHX1
ZMYM2
ZMYM3
ZMYM5
ZNF451
Entrez ID
10055
7341
HPRD ID
18010
03554
Ensembl ID
ENSG00000142230
ENSG00000116030
Uniprot IDs
A0A024R0R4
Q9UBE0
A0A024R3Z2
P63165
PDB IDs
1Y8Q
1Y8R
3KYC
3KYD
6CWY
6CWZ
1A5R
1TGZ
1WYW
1Y8R
1Z5S
2ASQ
2BF8
2G4D
2IO2
2IY0
2IY1
2KQS
2LAS
2MW5
2N1A
2N1V
2PE6
2UYZ
2VRR
3KYC
3KYD
3RZW
3UIP
4WJN
4WJO
4WJP
4WJQ
5AEK
5B7A
5ELJ
5GHD
6EOP
6EOT
6J4I
6JXU
6JXV
6K5T
6UYO
6UYP
6UYQ
6UYR
6UYS
6UYT
6UYU
6UYV
6UYX
6UYY
6UYZ
6V7P
6V7Q
6V7R
6V7S
6WW3
Enriched GO Terms of Interacting Partners
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