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GLRX5

Description glutaredoxin 5
Image
GO Annotations Cellular Component
  • Nucleus
  • Mitochondrion
  • Mitochondrial Matrix
  • Dendrite
  • Neuronal Cell Body
Molecular Function
  • Protein Binding
  • Protein Disulfide Oxidoreductase Activity
  • Metal Ion Binding
  • 2 Iron, 2 Sulfur Cluster Binding
Biological Process
  • Hemopoiesis
  • Small Molecule Metabolic Process
  • [2Fe-2S] Cluster Assembly
  • Protein Maturation By [2Fe-2S] Cluster Transfer
  • Protein Maturation By [4Fe-4S] Cluster Transfer
Pathways
  • Mitochondrial iron-sulfur cluster biogenesis
Drugs
Diseases
  • Erythropoietic porphyria (EP), including: Erythropoietic protoporphyria (EPP); Congenital erythropoietic porphyria (CEP); Gunther Disease; X-linked erythropoietic protoporphyria (XLEPP)
  • Sideroblastic anemia, including: Pyridoxine-refractory autosomal recessive sideroblastic anemia (PRARSA); X-linked sideroblastic anemia (XLSA); X-linked sideroblastic anemia with ataxia (ASAT)
GWAS
  • Amyotrophic lateral sclerosis (sporadic) ( 24529757)
  • Diisocyanate-induced asthma ( 25918132)
  • Mean corpuscular hemoglobin ( 32888494 27863252)
  • Mean corpuscular volume ( 32888494 27863252)
  • Mean reticulocyte volume ( 32888494)
  • Mean spheric corpuscular volume ( 32888494)
  • Obesity-related traits ( 23251661)
  • Refractive error ( 32231278)
Interacting Genes 4 interacting genes: APP BOLA1 BOLA3 KEAP1
Entrez ID 51218
HPRD ID 12659
Ensembl ID ENSG00000182512
Uniprot IDs A0A384MDT9 Q86SX6
PDB IDs 2MMZ 2WUL
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025