ORMDL3

Description		ORMDL sphingolipid biosynthesis regulator 3
Image		No pdb structure
GO Annotations	Cellular Component	Cell Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane SPOTS Complex Specific Granule Membrane
	Molecular Function	Protein Binding
	Biological Process	Ceramide Metabolic Process Neutrophil Degranulation Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Asthma ( 31619474 21150878 29273806 28461288 17611496 22561531) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 18587394 28067908 21102463) Hematological parameters ( 19820697) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 28425483 23000144 21399635 20639880) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Systemic sclerosis ( 28314753) Systemising ( 31508503) Type 1 diabetes ( 21829393 25751624 19430480) Ulcerative colitis ( 28067908 20228799 21297633) White blood cell count ( 27863252 21738480)
Interacting Genes		5 interacting genes: APP EEF1A1 LMNA LNX1 PTPN11
Entrez ID		94103
HPRD ID		17803
Ensembl ID		ENSG00000172057
Uniprot IDs		A0A024R1W6 Q8N138
PDB IDs
Enriched GO Terms of Interacting Partners?
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