NLRP12

Description		NLR family pyrin domain containing 12
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GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Dendritic Cell Migration Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MHC Class I Biosynthetic Process Regulation Of Interleukin-18 Biosynthetic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Negative Regulation Of Toll Signaling Pathway Negative Regulation Of Cytokine Secretion Negative Regulation Of Interleukin-1 Secretion Positive Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling
Pathways
Drugs
Diseases		Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Blood protein levels ( 29875488) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Testicular germ cell tumor ( 28604728)
Interacting Genes		3 interacting genes: FAF1 IRAK1 PYCARD
Entrez ID		91662
HPRD ID		14803
Ensembl ID		ENSG00000142405
Uniprot IDs		P59046
PDB IDs		2L6A 4XHS 5H7N
Enriched GO Terms of Interacting Partners?
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