EXO1

Description		exonuclease 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Nuclear Body
	Molecular Function	DNA Binding Chromatin Binding RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity 5'-3' Exodeoxyribonuclease Activity Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' Exodeoxyribonuclease Activity
	Biological Process	Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Replication DNA Repair Mismatch Repair DNA Recombination Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle RNA Phosphodiester Bond Hydrolysis, Endonucleolytic T-circle Formation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Basal cell carcinoma ( 31174203) Breast cancer ( 25751625 29059683) Keratinocyte cancer (MTAG) ( 31174203) Menopause (age at onset) ( 22267201 26414677)
Interacting Genes		18 interacting genes: ATM DCAF1 KPNA4 KPNB1 MLH1 MSH2 MSH3 PCNA PMS2 SENP6 SFN UBE2I YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		9156
HPRD ID		06932
Ensembl ID		ENSG00000174371
Uniprot IDs		A8K5H6 Q9UQ84
PDB IDs		3QE9 3QEA 3QEB 5UZV 5V04 5V05 5V06 5V07 5V08 5V09 5V0A 5V0B 5V0C 5V0D 5V0E
Enriched GO Terms of Interacting Partners?
Tagcloud ?