HERC2

Description		HECT and RLD domain containing E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centriole Cytosol Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding SUMO Binding
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Spermatogenesis Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Basal cell carcinoma ( 31174203) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Bone mineral content ( 31790847) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Colorectal cancer ( 29228715) Corneal astigmatism ( 30306274) Diisocyanate-induced asthma ( 25918132) Eye color ( 23548203 23118974 30664655) Eye color (brightness) ( 30664655) Eye color (hue) ( 30664655) Eye color (saturation) ( 30664655) Eye color traits ( 20463881 30166351) Glaucoma ( 30104761) Hair color ( 23548203 30664655 29662168 26926045) Hair morphology traits ( 30166351) Intraocular pressure ( 31959993) Iris color ( 18252221) Iris color (b* coordinate) ( 30895295) Iris color (L* coordinate) ( 30895295) Iris heterochromicity ( 30895295) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Monobrow ( 27182965) Perceived skin darkness ( 25963972) Red vs. brown/black hair color ( 30531825) Refractive astigmatism ( 30306274) Rosacea symptom severity ( 29771307) Skin colour saturation ( 25963972) Skin pigmentation ( 31315583 30664655) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 25963972) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Tanning ( 23548203) Uveal melanoma ( 28781888) Vitiligo ( 27723757 22561518)
Interacting Genes		12 interacting genes: CALM1 CDC42 ERG RNF11 STK11 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 UBE2N XPA
Entrez ID		8924
HPRD ID		06905
Ensembl ID		ENSG00000128731
Uniprot IDs		A8KAQ8 O95714
PDB IDs		2KEO 3KCI 4L1M
Enriched GO Terms of Interacting Partners?
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