SPHK1

Description		sphingosine kinase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Cell Junction Endocytic Vesicle Early Endosome Membrane Presynapse
	Molecular Function	Magnesium Ion Binding DNA Binding NAD+ Kinase Activity Protein Binding Calmodulin Binding ATP Binding Lipid Binding Sphinganine Kinase Activity Acetyltransferase Activity D-erythro-sphingosine Kinase Activity Sphingosine-1-phosphate Receptor Activity Protein Phosphatase 2A Binding
	Biological Process	Blood Vessel Development Sphingosine-1-phosphate Receptor Signaling Pathway Protein Folding Protein Acetylation Sphingosine Metabolic Process Inflammatory Response Brain Development Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Calcium-mediated Signaling Regulation Of Endocytosis Sphingolipid Biosynthetic Process Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-17 Production Response To Tumor Necrosis Factor Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Contraction Sphingosine Biosynthetic Process Sphingoid Catabolic Process Lipid Phosphorylation Positive Regulation Of Fibroblast Proliferation Regulation Of Phagocytosis Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide DNA Biosynthetic Process Regulation Of Neuroinflammatory Response Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Microglial Cell Activation Regulation Of Endosomal Vesicle Fusion
Pathways		Sphingolipid de novo biosynthesis Association of TriC/CCT with target proteins during biosynthesis VEGFR2 mediated cell proliferation Extra-nuclear estrogen signaling
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Lymphocyte counts ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		12 interacting genes: BIRC3 CTNND2 CTSB EP300 FYN LYN MBTPS1 RARG RPS6KC1 SPHKAP TRAF2 TRAF6
Entrez ID		8877
HPRD ID		04768
Ensembl ID		ENSG00000176170
Uniprot IDs		Q53ZR5 Q9NYA1
PDB IDs		3VZB 3VZC 3VZD 4L02 4V24
Enriched GO Terms of Interacting Partners?
Tagcloud ?