SETD3

Description		SET domain containing 3, actin histidine methyltransferase
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Transcription Coactivator Activity Actin Binding Protein Binding Protein-lysine N-methyltransferase Activity Protein-histidine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K4 Specific) Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	Histone H3-K36 Methylation Peptidyl-histidine Methylation Peptidyl-lysine Trimethylation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Actin Modification Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Muscle Cell Differentiation Histone H3-K4 Methylation Regulation Of Uterine Smooth Muscle Contraction
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Scalp hair shape ( 26926045) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		3 interacting genes: APP MYOD1 SRPK1
Entrez ID		84193
HPRD ID		08664
Ensembl ID		ENSG00000183576
Uniprot IDs		A0A024R6K3 Q86TU7
PDB IDs		3SMT 6ICT 6ICV 6MBJ 6MBK 6MBL 6OX0 6OX1 6OX2 6OX3 6OX4 6OX5
Enriched GO Terms of Interacting Partners?
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