KREMEN1

Description		kringle containing transmembrane protein 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane Neuronal Cell Body
	Molecular Function	Protein Binding
	Biological Process	Apoptotic Process Cell Communication Wnt Signaling Pathway Negative Regulation Of Ossification Negative Regulation Of Axon Regeneration Limb Development Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Drugs
Diseases
GWAS		Birth weight ( 31043758 27680694) Blood protein levels ( 30072576 29875488) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998) Pancreatic cancer ( 25086665) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		1 interacting genes: DKK1
Entrez ID		83999
HPRD ID		11182
Ensembl ID		ENSG00000183762
Uniprot IDs		Q96MU8
PDB IDs		5FWS 5FWT 5FWU 5FWV 5FWW
Enriched GO Terms of Interacting Partners?
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