FZD4

Description		frizzled class receptor 4
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Dendrite Clathrin-coated Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Glutamatergic Synapse
	Molecular Function	Amyloid-beta Binding Cytokine Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding Cytokine Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Protein Homodimerization Activity Wnt-activated Receptor Activity Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	Vasculogenesis G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Sensory Perception Of Sound Negative Regulation Of Cell-substrate Adhesion Wnt Signaling Pathway Cytokine-mediated Signaling Pathway Neuron Differentiation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Substrate Adhesion-dependent Cell Spreading Extracellular Matrix-cell Signaling Non-canonical Wnt Signaling Pathway Progesterone Secretion Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Retina Vasculature Morphogenesis In Camera-type Eye Cerebellum Vasculature Morphogenesis Retinal Blood Vessel Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Neuron Projection Arborization Cellular Response To Leukemia Inhibitory Factor
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD4 RNF mutants show enhanced WNT signaling and proliferation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases		Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS		Hepatocellular carcinoma in hepatitis B infection ( 26870257)
Interacting Genes		7 interacting genes: ARRB2 BAG6 DLG1 DLG2 DLG4 DVL2 MAGI3
Entrez ID		8322
HPRD ID		05203
Ensembl ID		ENSG00000174804
Uniprot IDs		Q9ULV1
PDB IDs		5BPB 5BPQ 5BQC 5BQE 5CL1 5CM4 5UWG 6BD4 6NE1
Enriched GO Terms of Interacting Partners?
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