RNF146

Description		ring finger protein 146
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Poly-ADP-D-ribose Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Degradation of AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
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Diseases
GWAS		Breast cancer ( 18326623) Diverticular disease ( 30177863) Food addiction ( 27106561) Intracranial volume ( 22504418) Subcortical brain region volumes ( 25607358) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: KASH5 PFN2 TGFBR1 TRAF2 TUBGCP4 UBE2D2 UBE2G2 UBE2H XRCC1 XRCC6
Entrez ID		81847
HPRD ID		11511
Ensembl ID		ENSG00000118518
Uniprot IDs		Q9NTX7
PDB IDs		2D8T 3V3L 6CF6
Enriched GO Terms of Interacting Partners?
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