CEP290

Description		centrosomal protein 290
Image		No pdb structure
GO Annotations	Cellular Component	Gamma-tubulin Complex Extracellular Region Nucleus Cytoplasm Centrosome Centriole Cytosol Membrane Photoreceptor Connecting Cilium Protein-containing Complex Centriolar Satellite Specific Granule Lumen Ciliary Transition Zone MKS Complex Ciliary Basal Body
	Molecular Function	Protein Binding Identical Protein Binding Microtubule Minus-end Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Hindbrain Development Otic Vesicle Formation Eye Photoreceptor Cell Development Neutrophil Degranulation Positive Regulation Of Transcription, DNA-templated Pronephros Development Cilium Assembly Regulation Of Establishment Of Protein Localization Positive Regulation Of Intracellular Protein Transport Ciliary Basal Body-plasma Membrane Docking
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2
Drugs
Diseases		Leber congenital amaurosis (LCR) Bardet-Biedl syndrome (BBS) Joubert syndrome Senior-Loken syndrome Meckel syndrome (MKS); Meckel-Gruber syndrome
GWAS		Clozapine-induced agranulocytosis ( 25187353) Mild influenza (H1N1) infection ( 26379185)
Interacting Genes		2 interacting genes: C9orf16 MAPK10
Entrez ID		80184
HPRD ID
Ensembl ID		ENSG00000198707
Uniprot IDs		O15078 Q05BJ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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