CACNB4

Description		calcium voltage-gated channel auxiliary subunit beta 4
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Synapse
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Chemical Synaptic Transmission Neuromuscular Junction Development Membrane Depolarization Cardiac Conduction Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Presynaptic depolarization and calcium channel opening NCAM1 interactions Phase 0 - rapid depolarisation Phase 2 - plateau phase
Drugs		Nimodipine Spironolactone Verapamil Mibefradil Dronedarone Trimebutine Manidipine
Diseases		Episodic ataxias Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Idiopathic dilated cardiomyopathy ( 29495422) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		10 interacting genes: CACNA1A CBX3 EFHC2 FASLG MAP1A MED31 PTN REM1 SYT1 TBL3
Entrez ID		785
HPRD ID		09057
Ensembl ID		ENSG00000182389
Uniprot IDs		A0A1B0GTK1 A0A1B0GTP5 A0A1B0GTX8 H0Y476 O00305
PDB IDs		2D46
Enriched GO Terms of Interacting Partners?
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