SPAST

Description		spastin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Centrosome Spindle Cytosol Microtubule Microtubule Cytoskeleton Integral Component Of Membrane Midbody Cytoplasmic Vesicle Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Axon Cytoplasm
	Molecular Function	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Isomerase Activity ATPase Activity Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding
	Biological Process	Mitotic Cytokinesis Microtubule Bundle Formation ER To Golgi Vesicle-mediated Transport Axonogenesis Anterograde Axonal Transport Metabolic Process Exit From Mitosis Axonal Transport Of Mitochondrion Positive Regulation Of Microtubule Depolymerization Cytoplasmic Microtubule Organization Nuclear Envelope Reassembly Positive Regulation Of Cytokinesis Cytokinetic Process Protein Hexamerization Microtubule Severing Mitotic Spindle Disassembly Protein Homooligomerization Cytoskeleton-dependent Cytokinesis Membrane Fission
Pathways		Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		4 interacting genes: CHMP1B IST1 RTN1 SSNA1
Entrez ID		6683
HPRD ID		05044
Ensembl ID		ENSG00000021574
Uniprot IDs		E5KRP5 E5KRP6 Q9UBP0
PDB IDs		3EAB 3VFD 5Z6Q 5Z6R
Enriched GO Terms of Interacting Partners?
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