DCLRE1C

Description		DNA cross-link repair 1C
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GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleoplasm Golgi Apparatus Nonhomologous End Joining Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Damaged DNA Binding Endonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-3' Exodeoxyribonuclease Activity
	Biological Process	Adaptive Immune Response Double-strand Break Repair Via Nonhomologous End Joining Response To Ionizing Radiation B Cell Differentiation Protection From Non-homologous End Joining At Telomere V(D)J Recombination Interstrand Cross-link Repair Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Nonhomologous End-Joining (NHEJ)
Drugs
Diseases		T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		11 interacting genes: ATM ATR BRCA1 CDKN1B DDB1 DDB2 MRE11 NBN PRKDC RAD50 TP53BP1
Entrez ID		64421
HPRD ID		05817
Ensembl ID		ENSG00000152457
Uniprot IDs		B3KMX5 Q96SD1
PDB IDs		3W1B 3W1G 4HTP
Enriched GO Terms of Interacting Partners?
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