SOX17

Description		SRY-box transcription factor 17
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nuclear Transcription Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coactivator Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Angiogenesis Vasculogenesis Metanephros Development Endoderm Formation Inner Cell Mass Cellular Morphogenesis Heart Looping Cardiogenic Plate Morphogenesis Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Regulation Of Transcription, DNA-templated Spermatogenesis Endodermal Cell Fate Determination Heart Development Anatomical Structure Morphogenesis Wnt Signaling Pathway Rostrocaudal Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Protein Destabilization Embryonic Heart Tube Development Cell Migration Involved In Gastrulation MRNA Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Embryonic Foregut Morphogenesis Stem Cell Fate Specification Protein Stabilization Endocardium Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Definitive Endodermal Cell Fate Specification Cardiac Cell Fate Determination Heart Formation Endocardial Cell Differentiation Common Bile Duct Development Gall Bladder Development Endodermal Digestive Tract Morphogenesis Regulation Of Stem Cell Proliferation Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Leukemia Inhibitory Factor Regulation Of Stem Cell Division Regulation Of Cardiac Cell Fate Specification
Pathways		Deactivation of the beta-catenin transactivating complex
Drugs
Diseases		Vesicoureteral reflux
GWAS		Cholesterol, total ( 24097068) Factor VIII levels ( 30586737) Intracranial aneurysm ( 18997786 20364137) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Pulmonary arterial hypertension ( 30527956) Total cholesterol levels ( 28334899)
Interacting Genes		1 interacting genes: CTNNB1
Entrez ID		64321
HPRD ID		18085
Ensembl ID		ENSG00000164736
Uniprot IDs		Q9H6I2
PDB IDs		2YUL 4A3N
Enriched GO Terms of Interacting Partners?
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