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RBBP5

Description RB binding protein 5, histone lysine methyltransferase complex subunit
Image
GO Annotations Cellular Component
  • Nucleus
  • Nucleoplasm
  • Nucleolus
  • Histone Methyltransferase Complex
  • MLL3/4 Complex
  • Set1C/COMPASS Complex
  • MLL1 Complex
Molecular Function
  • Protein Binding
  • Methylated Histone Binding
  • Histone Methyltransferase Activity (H3-K4 Specific)
  • Transcription Regulatory Region DNA Binding
Biological Process
  • Cellular Response To DNA Damage Stimulus
  • Response To Estrogen
  • Post-translational Protein Modification
  • Regulation Of Megakaryocyte Differentiation
  • Histone H3-K4 Methylation
  • Beta-catenin-TCF Complex Assembly
Pathways
  • Formation of the beta-catenin:TCF transactivating complex
  • PKMTs methylate histone lysines
  • Deactivation of the beta-catenin transactivating complex
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  • Neddylation
Drugs
Diseases
GWAS
  • Basophil percentage of granulocytes ( 27863252)
  • Blood protein levels ( 28240269)
  • Mean platelet volume ( 24026423)
Interacting Genes 11 interacting genes: ASH2L CHD8 CTBP1 CTNNB1 H3-4 H3C14 KMT2A KMT2B MEN1 RB1 UBE2I
Entrez ID 5929
HPRD ID 02826
Ensembl ID ENSG00000117222
Uniprot IDs A0A024R9B5 B4DLF8 Q15291
PDB IDs 3P4F 4X8N 4X8P 5F6K 5F6L 6KIU 6KIV 6KIW 6KIX 6KIZ 6KM7
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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