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PRSS1
Description
serine protease 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Collagen-containing Extracellular Matrix
Blood Microparticle
Molecular Function
Serine-type Endopeptidase Activity
Metal Ion Binding
Biological Process
Proteolysis
Digestion
Cobalamin Metabolic Process
Extracellular Matrix Disassembly
Pathways
Activation of Matrix Metalloproteinases
Cobalamin (Cbl, vitamin B12) transport and metabolism
Drugs
ZK-800270
Bis(5-Amidino-Benzimidazolyl)Methane
2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide
Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-Isopropylester
CRA_17693
N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl Ester
Hemi-Babim
CRA_10991
Monoisopropylphosphorylserine
[4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-Methanone
Bis(5-Amidino-2-Benzimidazolyl)Methanone
2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
5-Amidino-Benzimidazole
Amylamine
CRA_16847
Bis-Benzamidine
CRA_17312
Zk-806450
[4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-Ammonium
2-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-Carboxamidine
CRA_9334
4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine
CRA_10762
Aminomethylcyclohexane
2-(2-Hydroxy-Phenyl)-1h-Indole-5-Carboxamidine
Benzylamine
CRA_10655
Trans-2-Phenylcyclopropylamine
RPR131247
(2s,4r)-1-Acetyl-N-[(1s)-4-[(Aminoiminomethyl)Amino]-1-(2-Benzothiazolylcarbonyl)Butyl]-4-Hydroxy-2-Pyrrolidinecarboxamide
CRA_1802
CRA_10972
CRA_1801
Crc200 (Chiron-Behring)
Benzamidine
4-Iodobenzo[B]Thiophene-2-Carboxamidine
CRA_8696
CRA_10433
Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone
4-Fluorobenzylamine
RWJ-51084
1-(2-Amidinophenyl)-3-(Phenoxyphenyl)Urea
ZK-806711
3,5-Diiodotyrosine
1-(4-Tert-Butylcarbamoyl-Piperazine-1-Carbonyl)-3-(3-Guanidino-Propyl)-4-Oxo-Azetidine-2-Carboxylic Acid
Bis(5-Amidino-Benzimidazolyl)Methanone Zinc
CRA_11092
CRA_9785
Diminazene
CRA_1144
6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
Thieno[2,3-B]Pyridine-2-Carboxamidine
Phosphorylisopropane
Bis(5-Amidino-Benzimidazolyl)Methane Zinc
[(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl Ester
N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-Piperazine
CRA_9076
N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic Acid
CRA_23653
Cyclotheonamide A
Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone Hydrate
4-Phenylbutylamine
Phenethylamine
1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea
Aeruginosin 98-B
3-Phenylpropylamine
RPR128515
ZK-805623
2-(2-Oxo-1,2-Dihydro-Pyridin-3-Yl)-1h-Benzoimidazole-5-Carboxamidine
Benzo[B]Thiophene-2-Carboxamidine
CRA_10656
CRA_9678
4-PIPERIDIN-4-YLBUTANAL
2,5-bis-o-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-d-glucitol
2-O-(4'-AMIDINOPHENYL)-5-O-(3''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOL
2,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL
2-O-(3'-AMIDINOPHENYL)-5-O-(4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL
Aprotinin
diethyl [(1R)-1,5-diaminopentyl]boronate
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide
N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine
N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDE
2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide
(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide
(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide
3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATE
4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE
5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acid
+/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATE
2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE
2-NAPHTHALENESULFONIC ACID
1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID
](4-AMIDINOPHENYL)METHANE-PHOSPHONATE
Nafamostat
Diseases
Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS
Alcoholic chronic pancreatitis (
28754779
)
Cancer (
29299148
)
Meconium ileus in cystic fibrosis (
30807572
)
Methadone dose in opioid dependence (
28115739
)
Pancreatitis (
23143602
)
Interacting Genes
9 interacting genes:
DEFA5
LINC00839
PTPN4
SERPINA1
SERPINB13
SERPINB8
SERPINF2
SPINK5
TST
Entrez ID
5644
HPRD ID
02039
Ensembl ID
ENSG00000204983
Uniprot IDs
P07477
PDB IDs
1FXY
1TRN
2RA3
4WWY
4WXV
Enriched GO Terms of Interacting Partners
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