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PRF1

Description perforin 1
Image No pdb structure
GO Annotations Cellular Component
  • Extracellular Region
  • Cytosol
  • Plasma Membrane
  • Membrane
  • Integral Component Of Membrane
  • Endosome Lumen
  • Cytolytic Granule
Molecular Function
  • Calcium Ion Binding
  • Protein Binding
  • Wide Pore Channel Activity
  • Identical Protein Binding
Biological Process
  • Immunological Synapse Formation
  • T Cell Mediated Cytotoxicity
  • Defense Response To Tumor Cell
  • Immune Response To Tumor Cell
  • Apoptotic Process
  • Cellular Defense Response
  • Cytolysis
  • Protein Homooligomerization
  • Defense Response To Virus
  • Positive Regulation Of Killing Of Cells Of Other Organism
  • Transmembrane Transport
Pathways
Drugs
Diseases
  • Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS
  • Multiple keratinocyte cancers ( 28081215)
  • Obesity (extreme) ( 19553259)
Interacting Genes 5 interacting genes: CALR DDX24 GZMB KRT31 TRIM54
Entrez ID 5551
HPRD ID 01362
Ensembl ID ENSG00000180644
Uniprot IDs P14222
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?

© Madhavi K. Ganapathiraju 2012-2025

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