PMS2

Description		PMS1 homolog 2, mismatch repair system component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Mismatch Repair Complex MutLalpha Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding ATPase Activity Single Base Insertion Or Deletion Binding MutSalpha Complex Binding
	Biological Process	Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Response To Drug Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes
Drugs		Adenosine 5'-[Î³-thio]triphosphate
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS
Interacting Genes		4 interacting genes: EXO1 MLH1 PCNA UBC
Entrez ID		5395
HPRD ID		02598
Ensembl ID		ENSG00000122512
Uniprot IDs		A0A2R8Y6S3 B4DGM0 C9J167 P54278 Q7Z3Q2
PDB IDs		1EA6 1H7S 1H7U 5U5R 6MFQ
Enriched GO Terms of Interacting Partners?
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