NPC1

Description		NPC intracellular cholesterol transporter 1
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GO Annotations	Cellular Component	Extracellular Region Nuclear Envelope Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Late Endosome Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Integral Component Of Lysosomal Membrane
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Sterol Transporter Activity Cholesterol Binding Signaling Receptor Activity
	Biological Process	Protein Glycosylation Endocytosis Autophagy Lysosomal Transport Adult Walking Behavior Cholesterol Metabolic Process Bile Acid Metabolic Process Negative Regulation Of Macroautophagy Cholesterol Transport Membrane Raft Organization Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Response To Drug Cholesterol Homeostasis Response To Cadmium Ion Viral Entry Into Host Cell Negative Regulation Of Cell Death Cellular Response To Steroid Hormone Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Establishment Of Protein Localization To Membrane
Pathways		LDL clearance
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Body mass index ( 29273807) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Granulocyte count ( 27863252) HDL cholesterol ( 30275531) Household income (MTAG) ( 31844048) Mental health study participation (provided email address) ( 31263887) Metabolic syndrome ( 31589552) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity ( 19151714) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglycerides ( 30275531) White blood cell count ( 27863252)
Interacting Genes		2 interacting genes: MTDH VPS4A
Entrez ID		4864
HPRD ID		09622
Ensembl ID		ENSG00000141458
Uniprot IDs		O15118
PDB IDs		3GKH 3GKI 3GKJ 3JD8 5F18 5F1B 5HNS 5JNX 5KWY 5U73 5U74
Enriched GO Terms of Interacting Partners?
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